FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2294512444> ?p ?o ?g. }

• W2294512444 endingPage "3662" @default.
• W2294512444 startingPage "3651" @default.
• W2294512444 abstract "Molecular evolution of tumors during progression, therapy, and metastasis is a major clinical challenge and the main reason for resistance to therapy. We hypothesized that microRNAs (miRNAs) that exhibit similar variation of expression through the course of disease in several patients have a significant function in the tumorigenic process.Exploration of evolving disease by profiling 800 miRNA expression from serial samples of individual breast cancer patients at several time points: pretreatment, posttreatment, lymph nodes, and recurrence sites when available (58 unique samples from 19 patients). Using a dynamic approach for analysis, we identified expression modulation patterns and classified varying miRNAs into one of the eight possible temporal expression patterns.The various patterns were found to be associated with different tumorigenic pathways. The dominant pattern identified an miRNA set that significantly differentiated between disease stages, and its pattern in each patient was also associated with response to therapy. These miRNAs were related to tumor proliferation and to the cell-cycle pathway, and their mRNA targets showed anticorrelated expression. Interestingly, the level of these miRNAs was lowest in matched recurrent samples from distant metastasis, indicating a gradual increase in proliferative potential through the course of disease. Finally, the average expression level of these miRNAs in the pretreatment biopsy was significantly different comparing patients experiencing recurrence to recurrence-free patients.Serial tumor sampling combined with analysis of temporal expression patterns enabled to pinpoint significant signatures characterizing breast cancer progression, associated with response to therapy and with risk of recurrence. Clin Cancer Res; 22(14); 3651-62. ©2016 AACR." @default.
• W2294512444 created "2016-06-24" @default.
• W2294512444 creator A5000285825 @default.
• W2294512444 creator A5001211980 @default.
• W2294512444 creator A5009122309 @default.
• W2294512444 creator A5013027473 @default.
• W2294512444 creator A5032007880 @default.
• W2294512444 creator A5036299690 @default.
• W2294512444 creator A5050390557 @default.
• W2294512444 creator A5057779876 @default.
• W2294512444 creator A5062199973 @default.
• W2294512444 creator A5064166867 @default.
• W2294512444 creator A5070417437 @default.
• W2294512444 creator A5072041544 @default.
• W2294512444 creator A5077267151 @default.
• W2294512444 creator A5081908668 @default.
• W2294512444 creator A5084357214 @default.
• W2294512444 date "2016-07-14" @default.
• W2294512444 modified "2023-10-16" @default.
• W2294512444 title "Tumor Evolution Inferred by Patterns of microRNA Expression through the Course of Disease, Therapy, and Recurrence in Breast Cancer" @default.
• W2294512444 cites W1966063402 @default.
• W2294512444 cites W1966857167 @default.
• W2294512444 cites W1968328642 @default.
• W2294512444 cites W1981052185 @default.
• W2294512444 cites W1981794922 @default.
• W2294512444 cites W1984162437 @default.
• W2294512444 cites W1984753816 @default.
• W2294512444 cites W1999843039 @default.
• W2294512444 cites W2005895632 @default.
• W2294512444 cites W2008327230 @default.
• W2294512444 cites W2011417152 @default.
• W2294512444 cites W2023444929 @default.
• W2294512444 cites W2034729689 @default.
• W2294512444 cites W2039286144 @default.
• W2294512444 cites W2044198666 @default.
• W2294512444 cites W2050761481 @default.
• W2294512444 cites W2051352765 @default.
• W2294512444 cites W2057737812 @default.
• W2294512444 cites W2075664235 @default.
• W2294512444 cites W2080264320 @default.
• W2294512444 cites W2080726412 @default.
• W2294512444 cites W2083381199 @default.
• W2294512444 cites W2087900638 @default.
• W2294512444 cites W2094720383 @default.
• W2294512444 cites W2096145980 @default.
• W2294512444 cites W2096897393 @default.
• W2294512444 cites W2103592208 @default.
• W2294512444 cites W2115886559 @default.
• W2294512444 cites W2117391818 @default.
• W2294512444 cites W2120456037 @default.
• W2294512444 cites W2126540255 @default.
• W2294512444 cites W2128914123 @default.
• W2294512444 cites W2130410032 @default.
• W2294512444 cites W2132309202 @default.
• W2294512444 cites W2138775624 @default.
• W2294512444 cites W2139707713 @default.
• W2294512444 cites W2143688307 @default.
• W2294512444 cites W2148847151 @default.
• W2294512444 cites W2149785901 @default.
• W2294512444 cites W2157706516 @default.
• W2294512444 cites W2161677666 @default.
• W2294512444 cites W2164774797 @default.
• W2294512444 cites W2168877870 @default.
• W2294512444 cites W2170061824 @default.
• W2294512444 doi "https://doi.org/10.1158/1078-0432.ccr-15-2313" @default.
• W2294512444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26957561" @default.
• W2294512444 hasPublicationYear "2016" @default.
• W2294512444 type Work @default.
• W2294512444 sameAs 2294512444 @default.
• W2294512444 citedByCount "8" @default.
• W2294512444 countsByYear W22945124442016 @default.
• W2294512444 countsByYear W22945124442017 @default.
• W2294512444 countsByYear W22945124442018 @default.
• W2294512444 countsByYear W22945124442019 @default.
• W2294512444 countsByYear W22945124442020 @default.
• W2294512444 countsByYear W22945124442021 @default.
• W2294512444 countsByYear W22945124442022 @default.
• W2294512444 crossrefType "journal-article" @default.
• W2294512444 hasAuthorship W2294512444A5000285825 @default.
• W2294512444 hasAuthorship W2294512444A5001211980 @default.
• W2294512444 hasAuthorship W2294512444A5009122309 @default.
• W2294512444 hasAuthorship W2294512444A5013027473 @default.
• W2294512444 hasAuthorship W2294512444A5032007880 @default.
• W2294512444 hasAuthorship W2294512444A5036299690 @default.
• W2294512444 hasAuthorship W2294512444A5050390557 @default.
• W2294512444 hasAuthorship W2294512444A5057779876 @default.
• W2294512444 hasAuthorship W2294512444A5062199973 @default.
• W2294512444 hasAuthorship W2294512444A5064166867 @default.
• W2294512444 hasAuthorship W2294512444A5070417437 @default.
• W2294512444 hasAuthorship W2294512444A5072041544 @default.
• W2294512444 hasAuthorship W2294512444A5077267151 @default.
• W2294512444 hasAuthorship W2294512444A5081908668 @default.
• W2294512444 hasAuthorship W2294512444A5084357214 @default.
• W2294512444 hasBestOaLocation W22945124442 @default.
• W2294512444 hasConcept C104317684 @default.
• W2294512444 hasConcept C121608353 @default.
• W2294512444 hasConcept C126322002 @default.
• W2294512444 hasConcept C142724271 @default.

• next