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- W2294621167 endingPage "CCRPM.S23312" @default.
- W2294621167 startingPage "CCRPM.S23312" @default.
- W2294621167 abstract "Systemic sclerosis (SSc) is a connective tissue disease that is characterized by tissue fibrosis, microvasculopathy, and autoimmunity. Interstitial lung disease (ILD) is a common complication of SSc and is one of the frequent causes of mortality in SSc. Although the exact etiology of SSc remains unknown, clinical and experimental investigations have suggested that genetic and environmental factors are relevant to the pathogenesis of SSc and SSc-ILD. More than 30 genes have been identified as susceptibility loci for SSc, most of which are involved in immune regulation and inflammation. It is thought that the key pathogenesis of SSc-ILD is caused by the release of profibrotic mediators such as transforming growth factor β1 and connective tissue growth factor from lung cells induced by a persistent damage. This review presents the genetic susceptibility to SSc-ILD, including human leukocyte antigen and non-human leukocyte antigen genes, especially focusing on connective tissue growth factor." @default.
- W2294621167 created "2016-06-24" @default.
- W2294621167 creator A5062366510 @default.
- W2294621167 creator A5063192431 @default.
- W2294621167 creator A5087310684 @default.
- W2294621167 date "2015-01-01" @default.
- W2294621167 modified "2023-10-12" @default.
- W2294621167 title "Genetic Susceptibility to Interstitial Lung Disease Associated with Systemic Sclerosis" @default.
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- W2294621167 doi "https://doi.org/10.4137/ccrpm.s23312" @default.
- W2294621167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4791172" @default.
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