FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296103610> ?p ?o ?g. }

• W2296103610 abstract "Detailed immunocytochemical analyses comparing WT, GRF1 KO, GRF2 KO and GRF1/2 DKO mouse retinas uncovered the specific accumulation of misplaced, “ectopic” cone photoreceptor nuclei in the photoreceptor segment (PS) area of retinas from GRF2 KO and GRF1/2 DKO, but not of WT or GRF1 KO mice. The localization of “ectopic” nuclei in the PS area of GRF2-devoid retinas occurred postnatally and peaked between P11 and P15. Mechanistically, the generation of this phenotype involved disruption of the outer limiting membrane (OLM), and intrusion into the PS layer, of cone nuclei displaying significant perinuclear accumulation of signaling molecules known to participate in nuclear migration and cytoskeletal reorganization such as PAR3, PAR6, and activated, phosphorylated forms of PAK, MLC2 and VASP. Electroretinographic (ERG) recordings showed specific impairment of cone-mediated retinal function in GRF2 KO and GRF1/2 DKO retinas as compared to WT controls. These data identify defective cone nuclear migration as a novel phenotype in GRF2-devoid mouse retinas and support a critical role of GRF2 in control of the nuclear migration processes required for proper postnatal development and function of retinal cone photoreceptors." @default.
• W2296103610 created "2016-06-24" @default.
• W2296103610 creator A5010522599 @default.
• W2296103610 creator A5014895611 @default.
• W2296103610 creator A5015352154 @default.
• W2296103610 creator A5051625863 @default.
• W2296103610 creator A5082415118 @default.
• W2296103610 creator A5089744207 @default.
• W2296103610 date "2016-01-01" @default.
• W2296103610 modified "2023-09-30" @default.
• W2296103610 title "RasGRF2 controls nuclear migration in postnatal retinal cone photoreceptors" @default.
• W2296103610 cites W1624082697 @default.
• W2296103610 cites W1672592092 @default.
• W2296103610 cites W1910609371 @default.
• W2296103610 cites W1948361600 @default.
• W2296103610 cites W1965566484 @default.
• W2296103610 cites W1965593148 @default.
• W2296103610 cites W1968006347 @default.
• W2296103610 cites W1969874126 @default.
• W2296103610 cites W1970928680 @default.
• W2296103610 cites W1973269530 @default.
• W2296103610 cites W1975785018 @default.
• W2296103610 cites W1985462906 @default.
• W2296103610 cites W1986074141 @default.
• W2296103610 cites W1995405192 @default.
• W2296103610 cites W1995610071 @default.
• W2296103610 cites W2002212507 @default.
• W2296103610 cites W2006835596 @default.
• W2296103610 cites W2009495925 @default.
• W2296103610 cites W2013830847 @default.
• W2296103610 cites W2025044344 @default.
• W2296103610 cites W2033324702 @default.
• W2296103610 cites W2052254968 @default.
• W2296103610 cites W2052411635 @default.
• W2296103610 cites W2053971665 @default.
• W2296103610 cites W2059932450 @default.
• W2296103610 cites W2060719593 @default.
• W2296103610 cites W2061249433 @default.
• W2296103610 cites W2065594360 @default.
• W2296103610 cites W2065827852 @default.
• W2296103610 cites W2066556283 @default.
• W2296103610 cites W2067137855 @default.
• W2296103610 cites W2067855850 @default.
• W2296103610 cites W2068037860 @default.
• W2296103610 cites W2075570048 @default.
• W2296103610 cites W2076609940 @default.
• W2296103610 cites W2085655013 @default.
• W2296103610 cites W2087344433 @default.
• W2296103610 cites W2096024183 @default.
• W2296103610 cites W2101192001 @default.
• W2296103610 cites W2103668981 @default.
• W2296103610 cites W2104301336 @default.
• W2296103610 cites W2106051511 @default.
• W2296103610 cites W2108701018 @default.
• W2296103610 cites W2111239857 @default.
• W2296103610 cites W2132505232 @default.
• W2296103610 cites W2133300924 @default.
• W2296103610 cites W2150132566 @default.
• W2296103610 cites W2152166314 @default.
• W2296103610 cites W2152684087 @default.
• W2296103610 cites W2153551672 @default.
• W2296103610 cites W2155281294 @default.
• W2296103610 cites W2160261786 @default.
• W2296103610 cites W2170480036 @default.
• W2296103610 doi "https://doi.org/10.1242/jcs.180919" @default.
• W2296103610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26743081" @default.
• W2296103610 hasPublicationYear "2016" @default.
• W2296103610 type Work @default.
• W2296103610 sameAs 2296103610 @default.
• W2296103610 citedByCount "15" @default.
• W2296103610 countsByYear W22961036102016 @default.
• W2296103610 countsByYear W22961036102017 @default.
• W2296103610 countsByYear W22961036102018 @default.
• W2296103610 countsByYear W22961036102019 @default.
• W2296103610 countsByYear W22961036102020 @default.
• W2296103610 countsByYear W22961036102021 @default.
• W2296103610 countsByYear W22961036102022 @default.
• W2296103610 countsByYear W22961036102023 @default.
• W2296103610 crossrefType "journal-article" @default.
• W2296103610 hasAuthorship W2296103610A5010522599 @default.
• W2296103610 hasAuthorship W2296103610A5014895611 @default.
• W2296103610 hasAuthorship W2296103610A5015352154 @default.
• W2296103610 hasAuthorship W2296103610A5051625863 @default.
• W2296103610 hasAuthorship W2296103610A5082415118 @default.
• W2296103610 hasAuthorship W2296103610A5089744207 @default.
• W2296103610 hasBestOaLocation W22961036101 @default.
• W2296103610 hasConcept C104317684 @default.
• W2296103610 hasConcept C105702510 @default.
• W2296103610 hasConcept C127716648 @default.
• W2296103610 hasConcept C153911025 @default.
• W2296103610 hasConcept C169760540 @default.
• W2296103610 hasConcept C2777093970 @default.
• W2296103610 hasConcept C2778231335 @default.
• W2296103610 hasConcept C2780827179 @default.
• W2296103610 hasConcept C55493867 @default.
• W2296103610 hasConcept C86803240 @default.
• W2296103610 hasConcept C95444343 @default.
• W2296103610 hasConcept C97037327 @default.
• W2296103610 hasConceptScore W2296103610C104317684 @default.
• W2296103610 hasConceptScore W2296103610C105702510 @default.

• next