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• W2297306677 abstract "Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/l) through a carbohydrate-dependent interaction (50% inhibitory concentration for D-fructose, 12 mmol/l). This is the first report of a neutralizing HIV antibody displaying cross-reactivity with another pathogen, revealing that the carbohydrate neutralization determinant of HIV, defined by 2G12, is more widespread amongst immunogenic, microbial surfaces than previously recognized" @default.
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• W2297306677 date "2008-10-18" @default.
• W2297306677 modified "2023-10-16" @default.
• W2297306677 title "Antigenic mimicry of the HIV envelope by AIDS-associated pathogens" @default.
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• W2297306677 doi "https://doi.org/10.1097/qad.0b013e328314b5df" @default.
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