Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317362951> ?p ?o ?g. }
- W2317362951 endingPage "2444" @default.
- W2317362951 startingPage "2433" @default.
- W2317362951 abstract "mTor plays a central role in controlling protein homeostasis and cell survival. Recently, we have demonstrated that perturbations of mTor signaling are implicated in Alzheimer’s disease (AD) and that mTor complex 1 (mTorC1) is involved in the formation of toxic phospho-tau. Therefore, we employed mass-spectrometry-based proteomics to identify specific protein expression changes in relation with cell survival in human neuroblastoma SH-SY5Y cells expressing genetically modified mTor. Cell death in SH-SY5Y cells was induced by moderate serum deprivation. Using flow cytometry we observed that up-regulated mTor complex 2 (mTorC2) increases the number of viable cells. By using a combination approach of proteomic and enrichment analysis we have identified several proteins (Thioredoxin-dependent peroxide reductase, Peroxiredoxin-5, Cofilin 1 (non-muscle), Annexin A5, Mortalin, and 14-3-3 protein zeta/delta) involved in mitochondrial integrity, apoptotosis, and pro-survival functions (caspase inhibitor activity and anti-apoptosis) that were significantly altered by mTor activity modulation. The major findings of this study are the implication of mTorC2 but not mTorC1 in cell viability modulation by activating the pro-survival machinery. Taken together, these results suggest that up-regulated mTorC2 might be playing an important role in promoting cell survival by suppressing the mitochondria-caspase-apoptotic pathway in vitro." @default.
- W2317362951 created "2016-06-24" @default.
- W2317362951 creator A5001292166 @default.
- W2317362951 creator A5003599259 @default.
- W2317362951 creator A5005011787 @default.
- W2317362951 creator A5016018178 @default.
- W2317362951 creator A5026228369 @default.
- W2317362951 creator A5026323681 @default.
- W2317362951 creator A5041486662 @default.
- W2317362951 creator A5044622075 @default.
- W2317362951 creator A5049564136 @default.
- W2317362951 creator A5052661040 @default.
- W2317362951 creator A5061888725 @default.
- W2317362951 creator A5078169388 @default.
- W2317362951 creator A5081145920 @default.
- W2317362951 creator A5081283156 @default.
- W2317362951 creator A5086154974 @default.
- W2317362951 creator A5086664284 @default.
- W2317362951 date "2014-04-14" @default.
- W2317362951 modified "2023-10-18" @default.
- W2317362951 title "mTor Is a Signaling Hub in Cell Survival: A Mass-Spectrometry-Based Proteomics Investigation" @default.
- W2317362951 cites W1509666005 @default.
- W2317362951 cites W1518131650 @default.
- W2317362951 cites W1550326833 @default.
- W2317362951 cites W1581358998 @default.
- W2317362951 cites W1873073107 @default.
- W2317362951 cites W1934937165 @default.
- W2317362951 cites W1966308573 @default.
- W2317362951 cites W1972875881 @default.
- W2317362951 cites W1979268652 @default.
- W2317362951 cites W1983698019 @default.
- W2317362951 cites W1984909573 @default.
- W2317362951 cites W1995042713 @default.
- W2317362951 cites W2002692130 @default.
- W2317362951 cites W2003738638 @default.
- W2317362951 cites W2010560152 @default.
- W2317362951 cites W2010754109 @default.
- W2317362951 cites W2015556811 @default.
- W2317362951 cites W2018961056 @default.
- W2317362951 cites W2021933220 @default.
- W2317362951 cites W2022865222 @default.
- W2317362951 cites W2023316908 @default.
- W2317362951 cites W2031864556 @default.
- W2317362951 cites W2036011584 @default.
- W2317362951 cites W2037199116 @default.
- W2317362951 cites W2046431926 @default.
- W2317362951 cites W2047427096 @default.
- W2317362951 cites W2059124041 @default.
- W2317362951 cites W2060046173 @default.
- W2317362951 cites W2060905299 @default.
- W2317362951 cites W2065887259 @default.
- W2317362951 cites W2074769970 @default.
- W2317362951 cites W2075733006 @default.
- W2317362951 cites W2081236313 @default.
- W2317362951 cites W2094599199 @default.
- W2317362951 cites W2100463018 @default.
- W2317362951 cites W2111565853 @default.
- W2317362951 cites W2112078820 @default.
- W2317362951 cites W2114825009 @default.
- W2317362951 cites W2115094443 @default.
- W2317362951 cites W2117028091 @default.
- W2317362951 cites W2124684134 @default.
- W2317362951 cites W2127063807 @default.
- W2317362951 cites W2129585918 @default.
- W2317362951 cites W2131638245 @default.
- W2317362951 cites W2137349125 @default.
- W2317362951 cites W2147114673 @default.
- W2317362951 cites W2148570557 @default.
- W2317362951 cites W2153607816 @default.
- W2317362951 cites W2320360082 @default.
- W2317362951 cites W4238567307 @default.
- W2317362951 cites W4244649699 @default.
- W2317362951 doi "https://doi.org/10.1021/pr500192g" @default.
- W2317362951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24694195" @default.
- W2317362951 hasPublicationYear "2014" @default.
- W2317362951 type Work @default.
- W2317362951 sameAs 2317362951 @default.
- W2317362951 citedByCount "34" @default.
- W2317362951 countsByYear W23173629512014 @default.
- W2317362951 countsByYear W23173629512015 @default.
- W2317362951 countsByYear W23173629512016 @default.
- W2317362951 countsByYear W23173629512017 @default.
- W2317362951 countsByYear W23173629512018 @default.
- W2317362951 countsByYear W23173629512019 @default.
- W2317362951 countsByYear W23173629512020 @default.
- W2317362951 countsByYear W23173629512021 @default.
- W2317362951 crossrefType "journal-article" @default.
- W2317362951 hasAuthorship W2317362951A5001292166 @default.
- W2317362951 hasAuthorship W2317362951A5003599259 @default.
- W2317362951 hasAuthorship W2317362951A5005011787 @default.
- W2317362951 hasAuthorship W2317362951A5016018178 @default.
- W2317362951 hasAuthorship W2317362951A5026228369 @default.
- W2317362951 hasAuthorship W2317362951A5026323681 @default.
- W2317362951 hasAuthorship W2317362951A5041486662 @default.
- W2317362951 hasAuthorship W2317362951A5044622075 @default.
- W2317362951 hasAuthorship W2317362951A5049564136 @default.
- W2317362951 hasAuthorship W2317362951A5052661040 @default.
- W2317362951 hasAuthorship W2317362951A5061888725 @default.