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• W2326145004 abstract "Basic helix-loop-helix (bHLH) proneural proteins promote neurogenesis through transcriptional regulation. Although much is known about the tissue-specific regulation of proneural gene expression, how proneural proteins interact with transcriptional machinery to activate downstream target genes is less clear. Drosophila proneural proteins Achaete (Ac) and Scute (Sc) induce external sensory organ formation by activating neural precursor gene expression. Through co-immunoprecipitation and mass spectrometric analyses, we found that nuclear but not cytoplasmic actin associated with the Ac and Sc proteins in Drosophila S2 cells. Daughterless (Da), the common heterodimeric partner of Drosophila bHLH proteins, was observed to associate with nuclear actin via proneural proteins. A yeast two-hybrid assay revealed that the binding specificity between actin and Ac or Sc was conserved in yeast nuclei without the presence of additional Drosophila factors. We further show that actin is required in external sensory organ formation. Reduction in actin gene activity impaired proneural protein-dependent neural precursor gene expression as well as neural precursor formation. Furthermore, increased nuclear actin levels, by expression of nucleus-localized actin, elevated Ac/Da-dependent gene transcription as well as Ac-mediated external sensory organ formation. Taken together, our in vivo and in vitro observations suggest a novel link for actin in proneural protein-mediated transcriptional activation and neural precursor differentiation." @default.
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• W2326145004 date "2013-01-01" @default.
• W2326145004 modified "2023-09-27" @default.
• W2326145004 title "Proneural proteins Achaete and Scute associate with nuclear actin to promote external sensory organ formation" @default.
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• W2326145004 doi "https://doi.org/10.1242/jcs.134718" @default.
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