Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332588081> ?p ?o ?g. }
- W2332588081 endingPage "6598" @default.
- W2332588081 startingPage "6590" @default.
- W2332588081 abstract "Elastin-like polypeptides (ELPs) are a class of biopolymers consisting of the pentameric repeat (VPGαG)n based on the sequence of mammalian tropoelastin that display a thermally induced soluble-to-insoluble phase transition in aqueous solution. We have discovered a remarkably simple approach to driving the spontaneous self-assembly of high molecular weight ELPs into nanostructures by genetically fusing a short 1.5 kDa (XGy)z assembly domain to one end of the ELP. Classical theories of self-assembly based on the geometric mass balance of hydrophilic and hydrophobic block copolymers suggest that these highly asymmetric polypeptides should form spherical micelles. Surprisingly, when sufficiently hydrophobic amino acids (X) are presented in a periodic sequence such as (FGG)8 or (YG)8, these highly asymmetric polypeptides self-assemble into cylindrical micelles whose length can be tuned by the sequence of the morphogenic tag. These nanostructures were characterized by light scattering, tunable resistive pulse sensing, fluorescence spectrophotometry, and thermal turbidimetry, as well as by cryogenic transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). These short assembly domains provide a facile strategy to control the size, shape, and stability of stimuli responsive polypeptide nanostructures." @default.
- W2332588081 created "2016-06-24" @default.
- W2332588081 creator A5011079707 @default.
- W2332588081 creator A5011429387 @default.
- W2332588081 creator A5038324403 @default.
- W2332588081 creator A5044201568 @default.
- W2332588081 creator A5059067804 @default.
- W2332588081 creator A5061581484 @default.
- W2332588081 creator A5064908276 @default.
- W2332588081 creator A5085113267 @default.
- W2332588081 date "2014-10-02" @default.
- W2332588081 modified "2023-10-17" @default.
- W2332588081 title "Noncanonical Self-Assembly of Highly Asymmetric Genetically Encoded Polypeptide Amphiphiles into Cylindrical Micelles" @default.
- W2332588081 cites W1547937637 @default.
- W2332588081 cites W1857358013 @default.
- W2332588081 cites W1890647543 @default.
- W2332588081 cites W1966652815 @default.
- W2332588081 cites W1966703456 @default.
- W2332588081 cites W1967366094 @default.
- W2332588081 cites W1970204114 @default.
- W2332588081 cites W1975193857 @default.
- W2332588081 cites W1975771552 @default.
- W2332588081 cites W1979463458 @default.
- W2332588081 cites W1979849949 @default.
- W2332588081 cites W1985772681 @default.
- W2332588081 cites W1988506568 @default.
- W2332588081 cites W1990052437 @default.
- W2332588081 cites W1993053769 @default.
- W2332588081 cites W1996897223 @default.
- W2332588081 cites W2003390427 @default.
- W2332588081 cites W2003618149 @default.
- W2332588081 cites W2005004586 @default.
- W2332588081 cites W2006246299 @default.
- W2332588081 cites W2007308603 @default.
- W2332588081 cites W2008982039 @default.
- W2332588081 cites W2017064805 @default.
- W2332588081 cites W2018431651 @default.
- W2332588081 cites W2018557806 @default.
- W2332588081 cites W2020767725 @default.
- W2332588081 cites W2022549879 @default.
- W2332588081 cites W2023913432 @default.
- W2332588081 cites W2027587140 @default.
- W2332588081 cites W2028893730 @default.
- W2332588081 cites W2030498396 @default.
- W2332588081 cites W2031380487 @default.
- W2332588081 cites W2038052314 @default.
- W2332588081 cites W2046126135 @default.
- W2332588081 cites W2046613900 @default.
- W2332588081 cites W2047963707 @default.
- W2332588081 cites W2049138506 @default.
- W2332588081 cites W2065351060 @default.
- W2332588081 cites W2075370047 @default.
- W2332588081 cites W2082587127 @default.
- W2332588081 cites W2083680040 @default.
- W2332588081 cites W2085738178 @default.
- W2332588081 cites W2086626884 @default.
- W2332588081 cites W2087842405 @default.
- W2332588081 cites W2089633536 @default.
- W2332588081 cites W2106519778 @default.
- W2332588081 cites W2108831542 @default.
- W2332588081 cites W2121049170 @default.
- W2332588081 cites W2124159149 @default.
- W2332588081 cites W2129659516 @default.
- W2332588081 cites W2139519727 @default.
- W2332588081 cites W2142234529 @default.
- W2332588081 cites W2146639342 @default.
- W2332588081 cites W2152384518 @default.
- W2332588081 cites W2322017160 @default.
- W2332588081 cites W2329098197 @default.
- W2332588081 cites W2334086406 @default.
- W2332588081 cites W2334265885 @default.
- W2332588081 doi "https://doi.org/10.1021/nl503221p" @default.
- W2332588081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4246002" @default.
- W2332588081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25268037" @default.
- W2332588081 hasPublicationYear "2014" @default.
- W2332588081 type Work @default.
- W2332588081 sameAs 2332588081 @default.
- W2332588081 citedByCount "52" @default.
- W2332588081 countsByYear W23325880812015 @default.
- W2332588081 countsByYear W23325880812016 @default.
- W2332588081 countsByYear W23325880812017 @default.
- W2332588081 countsByYear W23325880812018 @default.
- W2332588081 countsByYear W23325880812019 @default.
- W2332588081 countsByYear W23325880812020 @default.
- W2332588081 countsByYear W23325880812021 @default.
- W2332588081 countsByYear W23325880812022 @default.
- W2332588081 crossrefType "journal-article" @default.
- W2332588081 hasAuthorship W2332588081A5011079707 @default.
- W2332588081 hasAuthorship W2332588081A5011429387 @default.
- W2332588081 hasAuthorship W2332588081A5038324403 @default.
- W2332588081 hasAuthorship W2332588081A5044201568 @default.
- W2332588081 hasAuthorship W2332588081A5059067804 @default.
- W2332588081 hasAuthorship W2332588081A5061581484 @default.
- W2332588081 hasAuthorship W2332588081A5064908276 @default.
- W2332588081 hasAuthorship W2332588081A5085113267 @default.
- W2332588081 hasBestOaLocation W23325880811 @default.
- W2332588081 hasConcept C11268172 @default.
- W2332588081 hasConcept C120665830 @default.