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- W2336883359 abstract "Background Aging is associated with decline in executive function (EF), upper-level cognitive abilities such as planning, problem solving, and working memory (WM). This decline is associated with age-related volume loss and reduced functional connectivity in the frontal lobes. Cognitive training interventions aim to counter these losses, but often fail to elicit benefits beyond improvements on trained tasks. Recent interventions pairing WM training with transcranial direct current stimulation (tDCS) have improved WM and elicited transfer to untrained EF tasks. Limitations in previous work include exclusive use of laboratory-based computer training and testing and poor characterization of the mechanism(s) of durable tDCS-linked change. Objective/Hypothesis To determine if tDCS-linked WM training improves performance on ecologically valid transfer measures administered in participants' homes. To explore intervention-based changes using neuroimaging (fNIRS) and genotyping (COMT val158met). Methods 90 healthy older adult participants completed 5 sessions of WM training paired with tDCS (Sham, 1 mA tDCS, 2 mA tDCS; 15 min). At follow-up, we assessed performance change on laboratory-based and ecologically valid tasks. Results All participants showed improvement on trained tasks. Importantly, 2 mA of tDCS induced significantly greater far transfer gains after 1 month without contact. Gains were observed on standard far transfer tasks along with ecologically valid far transfer tasks, and stimulation was well tolerated by all participants. FNIRS and genotyping results were less conclusive, but provide promising avenues for future research initiatives. Conclusion These findings highlight the translational value for tDCS-based interventions in healthy older adults interested in maintaining cognitive function." @default.
- W2336883359 created "2016-06-24" @default.
- W2336883359 creator A5009827232 @default.
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- W2336883359 date "2016-07-01" @default.
- W2336883359 modified "2023-10-16" @default.
- W2336883359 title "Older Adults Improve on Everyday Tasks after Working Memory Training and Neurostimulation" @default.
- W2336883359 cites W1847168837 @default.
- W2336883359 cites W1912879767 @default.
- W2336883359 cites W1968550300 @default.
- W2336883359 cites W1969969444 @default.
- W2336883359 cites W1971734091 @default.
- W2336883359 cites W1979140076 @default.
- W2336883359 cites W1981609408 @default.
- W2336883359 cites W1982993656 @default.
- W2336883359 cites W1985266789 @default.
- W2336883359 cites W1987007995 @default.
- W2336883359 cites W1991130661 @default.
- W2336883359 cites W1993177597 @default.
- W2336883359 cites W1994646558 @default.
- W2336883359 cites W1996548734 @default.
- W2336883359 cites W2005356040 @default.
- W2336883359 cites W2005859254 @default.
- W2336883359 cites W2007123023 @default.
- W2336883359 cites W2008854521 @default.
- W2336883359 cites W2024345501 @default.
- W2336883359 cites W2025264833 @default.
- W2336883359 cites W2027775882 @default.
- W2336883359 cites W2029802912 @default.
- W2336883359 cites W2030651552 @default.
- W2336883359 cites W2033237349 @default.
- W2336883359 cites W2037377025 @default.
- W2336883359 cites W2038138506 @default.
- W2336883359 cites W2040773973 @default.
- W2336883359 cites W2040896410 @default.
- W2336883359 cites W2045592453 @default.
- W2336883359 cites W2046132588 @default.
- W2336883359 cites W2052029838 @default.
- W2336883359 cites W2053464314 @default.
- W2336883359 cites W2057847098 @default.
- W2336883359 cites W2058161128 @default.
- W2336883359 cites W2060636544 @default.
- W2336883359 cites W2066692833 @default.
- W2336883359 cites W2078790263 @default.
- W2336883359 cites W2088384628 @default.
- W2336883359 cites W2095590115 @default.
- W2336883359 cites W2096674704 @default.
- W2336883359 cites W2098125329 @default.
- W2336883359 cites W2104177392 @default.
- W2336883359 cites W2108109897 @default.
- W2336883359 cites W2108150673 @default.
- W2336883359 cites W2112967992 @default.
- W2336883359 cites W2120749582 @default.
- W2336883359 cites W2123803218 @default.
- W2336883359 cites W2126851799 @default.
- W2336883359 cites W2130788353 @default.
- W2336883359 cites W2132326111 @default.
- W2336883359 cites W2132883636 @default.
- W2336883359 cites W2134066710 @default.
- W2336883359 cites W2137530396 @default.
- W2336883359 cites W2145610370 @default.
- W2336883359 cites W2147597108 @default.
- W2336883359 cites W2148080316 @default.
- W2336883359 cites W2151756070 @default.
- W2336883359 cites W2157152243 @default.
- W2336883359 cites W2160648917 @default.
- W2336883359 cites W2167311298 @default.
- W2336883359 cites W2167827175 @default.
- W2336883359 cites W2172250870 @default.
- W2336883359 cites W2412560454 @default.
- W2336883359 cites W4249948617 @default.
- W2336883359 cites W4290394325 @default.
- W2336883359 cites W4292806894 @default.
- W2336883359 cites W2008773326 @default.
- W2336883359 doi "https://doi.org/10.1016/j.brs.2016.04.001" @default.
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