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• W2337646301 endingPage "e13051" @default.
• W2337646301 startingPage "e13051" @default.
• W2337646301 abstract "NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance. Recently, synaptic plasticity has been studied in mouse barrel cortex, the primary sensory cortex for input from the animal's whiskers. Pharmacological data imply the presence of low-conductance NMDA receptors in spiny stellate neurons of cortical layer 4, but of high-conductance NMDA receptors in pyramidal neurons of layer 2/3. Here, to obtain complementary electrophysiological information on the functional NMDA receptors expressed in layer 4 and layer 2/3 neurons, single NMDA receptor currents were recorded with the patch-clamp method. Both cell types were found to contain high-conductance as well as low-conductance NMDA receptors. The results are consistent with the reported pharmacological data on synaptic plasticity, and with previous claims of a prominent role of low-conductance NMDA receptors in layer 4 spiny stellate neurons, including broad integration, amplification and distribution of excitation within the barrel in response to whisker stimulation, as well as modulation of excitability by ambient glutamate. However, layer 4 cells also expressed high-conductance NMDA receptors. The presence of low-conductance NMDA receptors in layer 2/3 pyramidal neurons suggests that some of these functions may be shared with layer 4 spiny stellate neurons." @default.
• W2337646301 created "2016-06-24" @default.
• W2337646301 creator A5044222715 @default.
• W2337646301 date "2016-12-01" @default.
• W2337646301 modified "2023-10-16" @default.
• W2337646301 title "High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex" @default.
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• W2337646301 doi "https://doi.org/10.14814/phy2.13051" @default.
• W2337646301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5210381" @default.
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• W2337646301 hasPublicationYear "2016" @default.
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