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- W2341235135 endingPage "130" @default.
- W2341235135 startingPage "87" @default.
- W2341235135 abstract "Oxidative stress is characterized by imbalanced reactive oxygen species (ROS) production and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system relies on molecules to directly quench ROS and the enzymatic system is composed of specific enzymes that detoxify ROS. Among the latter, the superoxide dismutase (SOD) family is important in oxidative stress modulation. Of these, manganese-dependent SOD (MnSOD) plays a major role due to its mitochondrial location, i.e., the main site of superoxide (O2•−) production. As such, extensive research has focused on its capacity to modulate oxidative stress. Early data demonstrated the relevance of MnSOD as an O2•− scavenger. More recent research has, however, identified a prominent role for MnSOD in carcinogenesis. In addition, SOD downregulation appears associated with health risk in heart and brain. A single nucleotide polymorphism which alters the mitochondria signaling sequence for the cytosolic MnSOD form has been identified. Transport into the mitochondria was differentially affected by allelic presence and a new chapter in MnSOD research thus begun. As a result, an ever-increasing number of diseases appear associated with this allelic variation including metabolic and cardiovascular disease. Although diet and exercise upregulate MnSOD, the relationship between environmental and genetic factors remains unclear." @default.
- W2341235135 created "2016-06-24" @default.
- W2341235135 creator A5039888859 @default.
- W2341235135 creator A5055089111 @default.
- W2341235135 creator A5084567869 @default.
- W2341235135 date "2015-01-01" @default.
- W2341235135 modified "2023-09-30" @default.
- W2341235135 title "Manganese Superoxide Dismutase and Oxidative Stress Modulation" @default.
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