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• W2343036789 abstract "Localization of ion channels and transporters to the correct membrane of polarized epithelia is important for vectorial ion movement. Prior studies have shown that the cytoplasmic carboxyl terminus of the cystic fibrosis transmembrane conductance regulator (CFTR) is involved in the apical localization of this protein. Here we show that the C-terminal tail alone, or when fused to the green fluorescent protein (GFP), can localize to the apical plasma membrane, despite the absence of transmembrane domains. Co-expression of the C terminus with full-length CFTR results in redistribution of CFTR from apical to basolateral membranes, indicating that both proteins interact with the same target at the apical membrane. Amino acid substitution and deletion analysis confirms the importance of a PDZ-binding motif D-T-R-L> for apical localization. However, two other C-terminal regions, encompassing amino acids 1370-1394 and 1404-1425 of human CFTR, are also required for localizing to the apical plasma membrane. Based on these results, we propose a model of polarized distribution of CFTR, which includes a mechanism of selective retention of this protein in the apical plasma membrane and stresses the requirement for other C-terminal sequences in addition to a PDZ-binding motif." @default.
• W2343036789 created "2016-06-24" @default.
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• W2343036789 date "2001-02-15" @default.
• W2343036789 modified "2023-10-01" @default.
• W2343036789 title "A PDZ-binding motif is essential but not sufficient to localize the C terminus of CFTR to the apical membrane" @default.
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• W2343036789 doi "https://doi.org/10.1242/jcs.114.4.719" @default.
• W2343036789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11171377" @default.
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