FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344579399> ?p ?o ?g. }

• W2344579399 endingPage "847" @default.
• W2344579399 startingPage "841" @default.
• W2344579399 abstract "Changes in phosphoinositide metabolism were examined in washed rabbit platelets stimulated with 0.5 microM-ADP, 50 microM-adrenaline, or ADP and adrenaline in combination. Adrenaline does not stimulate platelet aggregation when used alone, but does potentiate aggregation stimulated by ADP. In platelets prelabelled with [32P]Pi and [3H]glycerol, adrenaline was found to potentiate the ADP-induced changes in platelet phospholipids, causing larger increases in the amount and labelling of phosphatidylinositol 4-phosphate (PIP) and phosphatidic acid than was observed with ADP alone. The combination of ADP and adrenaline did not produce a greater decrease in phosphatidylinositol 4,5-bisphosphate (PIP2) than was produced by ADP alone. In platelets prelabelled with [3H]inositol, adrenaline potentiated the increases in labelling of inositol phosphate and inositol bisphosphate stimulated by ADP; no increase in inositol trisphosphate labelling was detected with ADP alone or with the combination of ADP and adrenaline. Phentolamine, an alpha-adrenergic-receptor antagonist, blocked potentiation by adrenaline of ADP-induced changes in phosphoinositide metabolism. Propranolol and sotalol, beta-adrenergic-receptor antagonists, augmented the potentiation; this is consistent with the concept that the effect of adrenaline is mediated by beta-adrenergic receptors. The effect of adrenaline on phosphoinositide metabolism appears to be to potentiate the mechanisms by which ADP causes turnover of PIP and possibly degradation of PI, rather than the mechanism by which PIP2 is decreased." @default.
• W2344579399 created "2016-06-24" @default.
• W2344579399 creator A5031597095 @default.
• W2344579399 creator A5034948302 @default.
• W2344579399 creator A5047651306 @default.
• W2344579399 creator A5077888084 @default.
• W2344579399 date "1987-03-15" @default.
• W2344579399 modified "2023-09-26" @default.
• W2344579399 title "Involvement of phosphoinositide metabolism in potentiation by adrenaline of ADP-induced aggregation of rabbit platelets" @default.
• W2344579399 cites W102045258 @default.
• W2344579399 cites W1495030769 @default.
• W2344579399 cites W1559778399 @default.
• W2344579399 cites W1598199924 @default.
• W2344579399 cites W1896310453 @default.
• W2344579399 cites W1927894522 @default.
• W2344579399 cites W1964100059 @default.
• W2344579399 cites W1987551802 @default.
• W2344579399 cites W1988204563 @default.
• W2344579399 cites W2002271390 @default.
• W2344579399 cites W2005313562 @default.
• W2344579399 cites W2008862271 @default.
• W2344579399 cites W2019572898 @default.
• W2344579399 cites W2027869648 @default.
• W2344579399 cites W2033482327 @default.
• W2344579399 cites W2056798741 @default.
• W2344579399 cites W2059609063 @default.
• W2344579399 cites W2086090144 @default.
• W2344579399 cites W2113136677 @default.
• W2344579399 cites W2141340123 @default.
• W2344579399 cites W2290735720 @default.
• W2344579399 cites W2312981770 @default.
• W2344579399 cites W2338315462 @default.
• W2344579399 cites W2342122062 @default.
• W2344579399 cites W23488299 @default.
• W2344579399 cites W2412020806 @default.
• W2344579399 cites W2412964675 @default.
• W2344579399 cites W2426879402 @default.
• W2344579399 cites W2463061879 @default.
• W2344579399 cites W331724197 @default.
• W2344579399 cites W84220812 @default.
• W2344579399 cites W86588746 @default.
• W2344579399 doi "https://doi.org/10.1042/bj2420841" @default.
• W2344579399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1147786" @default.
• W2344579399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3036103" @default.
• W2344579399 hasPublicationYear "1987" @default.
• W2344579399 type Work @default.
• W2344579399 sameAs 2344579399 @default.
• W2344579399 citedByCount "13" @default.
• W2344579399 crossrefType "journal-article" @default.
• W2344579399 hasAuthorship W2344579399A5031597095 @default.
• W2344579399 hasAuthorship W2344579399A5034948302 @default.
• W2344579399 hasAuthorship W2344579399A5047651306 @default.
• W2344579399 hasAuthorship W2344579399A5077888084 @default.
• W2344579399 hasBestOaLocation W23445793992 @default.
• W2344579399 hasConcept C11960822 @default.
• W2344579399 hasConcept C126322002 @default.
• W2344579399 hasConcept C134018914 @default.
• W2344579399 hasConcept C170493617 @default.
• W2344579399 hasConcept C185592680 @default.
• W2344579399 hasConcept C25274449 @default.
• W2344579399 hasConcept C2775859304 @default.
• W2344579399 hasConcept C2776909261 @default.
• W2344579399 hasConcept C2777427919 @default.
• W2344579399 hasConcept C2778151854 @default.
• W2344579399 hasConcept C2778618036 @default.
• W2344579399 hasConcept C2778918659 @default.
• W2344579399 hasConcept C2780610907 @default.
• W2344579399 hasConcept C2781387506 @default.
• W2344579399 hasConcept C41625074 @default.
• W2344579399 hasConcept C55493867 @default.
• W2344579399 hasConcept C71924100 @default.
• W2344579399 hasConcept C86803240 @default.
• W2344579399 hasConcept C89560881 @default.
• W2344579399 hasConceptScore W2344579399C11960822 @default.
• W2344579399 hasConceptScore W2344579399C126322002 @default.
• W2344579399 hasConceptScore W2344579399C134018914 @default.
• W2344579399 hasConceptScore W2344579399C170493617 @default.
• W2344579399 hasConceptScore W2344579399C185592680 @default.
• W2344579399 hasConceptScore W2344579399C25274449 @default.
• W2344579399 hasConceptScore W2344579399C2775859304 @default.
• W2344579399 hasConceptScore W2344579399C2776909261 @default.
• W2344579399 hasConceptScore W2344579399C2777427919 @default.
• W2344579399 hasConceptScore W2344579399C2778151854 @default.
• W2344579399 hasConceptScore W2344579399C2778618036 @default.
• W2344579399 hasConceptScore W2344579399C2778918659 @default.
• W2344579399 hasConceptScore W2344579399C2780610907 @default.
• W2344579399 hasConceptScore W2344579399C2781387506 @default.
• W2344579399 hasConceptScore W2344579399C41625074 @default.
• W2344579399 hasConceptScore W2344579399C55493867 @default.
• W2344579399 hasConceptScore W2344579399C71924100 @default.
• W2344579399 hasConceptScore W2344579399C86803240 @default.
• W2344579399 hasConceptScore W2344579399C89560881 @default.
• W2344579399 hasIssue "3" @default.
• W2344579399 hasLocation W23445793991 @default.
• W2344579399 hasLocation W23445793992 @default.
• W2344579399 hasLocation W23445793993 @default.
• W2344579399 hasLocation W23445793994 @default.
• W2344579399 hasOpenAccess W2344579399 @default.

• next