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• W2346103687 abstract "Eccentric exercise can result in muscle damage and interleukin-6 (IL-6) secretion. Glycogen availability is a potent stimulator of IL-6 secretion. We examined effects of eccentric exercise in a low-glycogen state on neuromuscular function and plasma IL-6 secretion. Twelve active men (23 ± 4 yr, 179 ± 5 cm, 77 ± 10 kg, means ± SD) completed two downhill treadmill runs (gradient, -12%, 5 × 8 min; speed, 12.1 ± 1.1 km/h) with normal (NG) and reduced muscle glycogen (RG) in randomized order and at least 6 wk apart. Muscle glycogen was reduced using an established cycling protocol until exhaustion and dietary manipulation the evening before the morning run. Physiological responses were measured up to 48 h after the downhill runs. During recovery, force deficits of musculus quadriceps femoris by maximal isometric contractions were similar. Changes in low-frequency fatigue were larger with RG. Voluntary activation and plasma IL-6 levels were similar in recovery between conditions. It is concluded that unaccustomed, damaging eccentric exercise with low muscle glycogen of the m. quadriceps femoris 1) exacerbated low-frequency fatigue but 2) had no additional effect on IL-6 secretion. Neuromuscular impairment after eccentric exercise with low muscle glycogen appears to have a greater peripheral component in early recovery." @default.
• W2346103687 created "2016-06-24" @default.
• W2346103687 creator A5035645839 @default.
• W2346103687 creator A5077327976 @default.
• W2346103687 creator A5078878221 @default.
• W2346103687 date "2016-05-05" @default.
• W2346103687 modified "2023-10-16" @default.
• W2346103687 title "Effect of eccentric exercise with reduced muscle glycogen on plasma interleukin-6 and neuromuscular responses of musculus quadriceps femoris" @default.
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• W2346103687 doi "https://doi.org/10.1152/japplphysiol.00383.2015" @default.
• W2346103687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27150832" @default.
• W2346103687 hasPublicationYear "2016" @default.
• W2346103687 type Work @default.
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