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• W2363670673 abstract "* OBJECTIVE: To investigate the use of the photosensitizer hypocrellin A as a photodynamic agent to occlude the choriocapillaris in the eyes of pigmented rabbits. * METHODS: Hypocrellin A (500 µg/kg) incorporated into liposomes was injected intravenously in pigmented rabbits. Ten to 15 minutes later, the retinas were irradiated with a dye laser (spot size, 2 mm; 1060 mW; 10-60 seconds; fluences 3.2 to 95.5 J/cm p 2 ) at two wavelengths: yellow (568 nm) and red (647 nm). Fluorescein angiography was performed 2 and 24 hours later. Parallel controls were irradiated without a photosensitizer. Histology was performed immediately after the 24-hour angiogram. * RESULTS: A photodynamic response was observed 24 hours after PDT in eyes subjected to yellow laser irradiation at 20 mW for 60 seconds (fluence, 38.2 J/cm p 2 ) and at higher powers for lesser durations: 30 mW for 40 seconds (fluence, 38.2 J/cm p 2 ), 40 mW for 20 seconds (fluence, 25.4 J/cm p 2 ), and 50 and 60 mWfor 10 seconds (fluences, 15.9 and 19.1 J/cm p 2 , respectively). Light microscopy showed occlusion of the choriocapillaris in all eyes with angiographic responses. Control eyes and eyes irradiated with the red laser revealed no angiographic or histologic changes. * CONCLUSION: Photodynamic therapy using liposomal hypocrellin A and the yellow laser of 568 nm was effective in occluding the choriocapillaris of pigmented rabbits. [Ophthalmic Surg Lasers 2002;33:207-213]" @default.
• W2363670673 created "2016-06-24" @default.
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• W2363670673 date "2002-05-01" @default.
• W2363670673 modified "2023-09-25" @default.
• W2363670673 title "Experimental Photodynamic Effects of Hypocrellin A on the Choriocapillaris" @default.
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• W2363670673 doi "https://doi.org/10.3928/1542-8877-20020501-07" @default.
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