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• W2388421036 abstract "Understanding how new species form requires investigation of evolutionary forces that cause phenotypic and genotypic changes among populations. However, the mechanisms underlying speciation vary and little is known about whether genomes diversify in the same ways in parallel at the incipient scale. We address this using the nematode, Pristionchus pacificus, which resides at an interesting point on the speciation continuum (distinct evolutionary lineages without reproductive isolation), and inhabits heterogeneous environments subject to divergent environmental pressures. Using whole genome re-sequencing of 264 strains, we estimate FST to identify outlier regions of extraordinary differentiation (∼1.725 Mb of the 172.5 Mb genome). We find evidence for shared divergent genomic regions occurring at a higher frequency than expected by chance among populations of the same evolutionary lineage. We use allele frequency spectra to find that, among lineages, 53% of divergent regions are consistent with adaptive selection, whereas 24% and 23% of such regions suggest background selection and restricted gene flow, respectively. In contrast, among populations from the same lineage, similar proportions (34–48%) of divergent regions correspond to adaptive selection and restricted gene flow, whereas 13–22% suggest background selection. Because speciation often involves phenotypic and genomic divergence, we also evaluate phenotypic variation, focusing on pH tolerance, which we find is diverging in a manner corresponding to environmental differences among populations. Taking a genome-wide association approach, we functionally validate a significant genotype–phenotype association for this trait. Our results are consistent with P. pacificus undergoing heterogeneous genotypic and phenotypic diversification related to both evolutionary and environmental processes." @default.
• W2388421036 created "2016-06-24" @default.
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• W2388421036 date "2016-05-09" @default.
• W2388421036 modified "2023-10-03" @default.
• W2388421036 title "Genomic Profiles of Diversification and Genotype–Phenotype Association in Island Nematode Lineages" @default.
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• W2388421036 doi "https://doi.org/10.1093/molbev/msw093" @default.
• W2388421036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27189551" @default.
• W2388421036 hasPublicationYear "2016" @default.
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