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• W2400979244 abstract "Liver injury is a major hindrance to the treatment of tuberculosis (TB) patients due to the primary side effects associated with anti‑TB drugs. Several investigations have identified sensitive biomarkers for the early diagnosis of anti-TB drug-induced liver injury (ADLI), including the use of microRNAs (miRNAs/miRs). However, the association between miR‑122/155 and ADLI remains unknown. Thus, the present study used reverse transcription‑quantitative polymerase chain reaction to observe changes in tissue miR‑122/155 expression levels during the course of liver injury in mice. Liver injury was induced by the administration of isoniazid (INH), a first‑line anti‑TB drug. miR‑122/155 expression levels were quantified at seven time points throughout 1 day (0.25, 0.75, 1.5, 6, 12, 18 and 24 h) based on the pharmacokinetics of INH in mice. Notably, over the timecourse of INH‑induced liver injury, the tissue miR‑122 expression level significantly decreased at 0.25 h, which is the peak concentration time of INH, compared with the control group (P<0.05). The change was more rapid than that of the serum aminotransferase and miR‑155, which were significantly increased at 0.75 h. In addition, the pathological score correlated with the ratio of miR-122/miR-155 (r=‑0.779; P<0.01). In conclusion, the miR‑122/155 ratio may be utilized as a sensitive biomarker for ADLI, which could contribute to the early diagnosis of patients following anti-TB treatment." @default.
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• W2400979244 date "2016-05-20" @default.
• W2400979244 modified "2023-09-27" @default.
• W2400979244 title "Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice" @default.
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• W2400979244 doi "https://doi.org/10.3892/etm.2016.3375" @default.
• W2400979244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4950840" @default.
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