Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413691910> ?p ?o ?g. }
- W2413691910 endingPage "1000" @default.
- W2413691910 startingPage "20988" @default.
- W2413691910 abstract "Mismatch repair defective (MMRd) colorectal carcinoma (CRC) is a distinct molecular phenotype of colorectal cancer, including 12% of sporadic CRC and 3% of Lynch Syndrome. In order to investigate the clinicopathological characteristics of MMRd colorectal carcinoma, and to find the most effective method for preliminary screening, 296 CRC fulfilled revised Bethesda Guideline (RB) were selected from 1450 CRCs to perform both IHC staining for MLH1, MSH2, MSH6, PMS2 and MSI analysis. Sixty-eight tumors were classified as MSI-H by MSI test. Colorectal carcinomas with MSI-H were prone to be proximal located, poorly differentiated, and relatively early staged, with infrequent metastasis to lymph node as well as to distant organs, compared with MSS ones. All of the 68 MMRd CRCs presented abnormal expression of at least one mismatch repair protein (MMRP), with 48 concurrent negative of MLH1 and PMS2, 14 concurrent negative of MSH2 and MSH6, 4 isolated negative of MSH6, 1 isolated negative of PMS2, and 1 concurrent negative of 4 MMRPs. All of the MLH1 negative tumors also showed abnormal expression of PMS2. All of the MSH2 negative cases also presented negative expression of MSH6. The sensitivity and specificity of the 2-antibody IHC test contained only PMS2 and MSH6 for screening for MMRd CRC were 100% and 98.2% respectively, exactly the same as that of the 4-antibody IHC test with all of the 4 MMRPs. The diagnostic accordance rate of the 2-antibody approach and MSI analysis was 98.6%. In conclusion, MMRd CRC has characteristic clinicopathological features different from MSS CRCs. The 2-antibody IHC approach containing MSH6 and PMS2 is the most easy and effective way to detecting MMR deficiency in CRC." @default.
- W2413691910 created "2016-06-24" @default.
- W2413691910 creator A5011715666 @default.
- W2413691910 creator A5017045221 @default.
- W2413691910 creator A5023037940 @default.
- W2413691910 creator A5038992198 @default.
- W2413691910 creator A5060642200 @default.
- W2413691910 creator A5079132855 @default.
- W2413691910 creator A5084173925 @default.
- W2413691910 creator A5089520253 @default.
- W2413691910 date "2015-01-01" @default.
- W2413691910 modified "2023-10-16" @default.
- W2413691910 title "Immunohistochemistry and microsatellite instability analysis in molecular subtyping of colorectal carcinoma based on mismatch repair competency." @default.
- W2413691910 cites W1504535992 @default.
- W2413691910 cites W1520825092 @default.
- W2413691910 cites W1533526450 @default.
- W2413691910 cites W1534073104 @default.
- W2413691910 cites W1538930506 @default.
- W2413691910 cites W1926715094 @default.
- W2413691910 cites W1940241680 @default.
- W2413691910 cites W1961988123 @default.
- W2413691910 cites W1964416791 @default.
- W2413691910 cites W1968028641 @default.
- W2413691910 cites W1976397607 @default.
- W2413691910 cites W1976786479 @default.
- W2413691910 cites W1984887162 @default.
- W2413691910 cites W1986937402 @default.
- W2413691910 cites W1993883670 @default.
- W2413691910 cites W1995819860 @default.
- W2413691910 cites W1997706585 @default.
- W2413691910 cites W2004090060 @default.
- W2413691910 cites W2016124215 @default.
- W2413691910 cites W2020399224 @default.
- W2413691910 cites W2024346369 @default.
- W2413691910 cites W2027434085 @default.
- W2413691910 cites W2032983127 @default.
- W2413691910 cites W2033689666 @default.
- W2413691910 cites W2038961252 @default.
- W2413691910 cites W2039220388 @default.
- W2413691910 cites W2041758733 @default.
- W2413691910 cites W2045044035 @default.
- W2413691910 cites W2047524584 @default.
- W2413691910 cites W2055993339 @default.
- W2413691910 cites W2061343866 @default.
- W2413691910 cites W2064854706 @default.
- W2413691910 cites W2066549535 @default.
- W2413691910 cites W2075574386 @default.
- W2413691910 cites W2079825994 @default.
- W2413691910 cites W2083894375 @default.
- W2413691910 cites W2084134833 @default.
- W2413691910 cites W2085087786 @default.
- W2413691910 cites W2085236246 @default.
- W2413691910 cites W2092886152 @default.
- W2413691910 cites W2094390470 @default.
- W2413691910 cites W2096371251 @default.
- W2413691910 cites W2096857955 @default.
- W2413691910 cites W2099797333 @default.
- W2413691910 cites W2103547637 @default.
- W2413691910 cites W2106787323 @default.
- W2413691910 cites W2107852315 @default.
- W2413691910 cites W2123281629 @default.
- W2413691910 cites W2123636561 @default.
- W2413691910 cites W2124841274 @default.
- W2413691910 cites W2127330908 @default.
- W2413691910 cites W2127951115 @default.
- W2413691910 cites W2128793721 @default.
- W2413691910 cites W2130830134 @default.
- W2413691910 cites W2133638941 @default.
- W2413691910 cites W2145297551 @default.
- W2413691910 cites W2145494417 @default.
- W2413691910 cites W2147698761 @default.
- W2413691910 cites W2149056832 @default.
- W2413691910 cites W2150625137 @default.
- W2413691910 cites W2152681282 @default.
- W2413691910 cites W2154546296 @default.
- W2413691910 cites W2159429807 @default.
- W2413691910 cites W2160550688 @default.
- W2413691910 cites W4211199921 @default.
- W2413691910 cites W4237862172 @default.
- W2413691910 cites W2013469922 @default.
- W2413691910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4723875" @default.
- W2413691910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26885030" @default.
- W2413691910 hasPublicationYear "2015" @default.
- W2413691910 type Work @default.
- W2413691910 sameAs 2413691910 @default.
- W2413691910 citedByCount "25" @default.
- W2413691910 countsByYear W24136919102016 @default.
- W2413691910 countsByYear W24136919102017 @default.
- W2413691910 countsByYear W24136919102018 @default.
- W2413691910 countsByYear W24136919102019 @default.
- W2413691910 countsByYear W24136919102020 @default.
- W2413691910 countsByYear W24136919102021 @default.
- W2413691910 countsByYear W24136919102022 @default.
- W2413691910 countsByYear W24136919102023 @default.
- W2413691910 crossrefType "journal-article" @default.
- W2413691910 hasAuthorship W2413691910A5011715666 @default.
- W2413691910 hasAuthorship W2413691910A5017045221 @default.
- W2413691910 hasAuthorship W2413691910A5023037940 @default.