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• W2416366909 abstract "Drugs with low aqueous solubility and permeability possess substantial challenges in designing effective and safe formulations. Synergistic solubility and permeability enhancement in a simple formulation can increase bioavailability and efficacy of such drugs. To overcome limitations of the clinical formulation of Taxol®, Paclitaxel (PTX) was reformulated with various β-cyclodextrin (CD) derivatives suitable for parenteral administration. Results indicated that β-CDs can efficiently form complexes with PTX at lower molar ratios, enhance aqueous solubility up to 500 times and improved cellular internalization of PTX. All β-CD derivatives were found to be safe as excipient since none showed detectable signs of cyto-genotoxicity. As a result, the CD-PTX complexes significantly increased the cytotoxicity of the drug. The study concluded that CD-PTX formulations could substitute the current intravenous infusion of PTX obviating the use of non-inert excipient Cremophor EL." @default.
• W2416366909 created "2016-06-24" @default.
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• W2416366909 date "2015-01-01" @default.
• W2416366909 modified "2023-10-15" @default.
• W2416366909 title "Molecular Inclusion Complexes of β-Cyclodextrin Derivatives Enhance Aqueous Solubility and Cellular Internalization of Paclitaxel: Preformulation and In vitro Assessments" @default.
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• W2416366909 doi "https://doi.org/10.13188/2327-204x.1000011" @default.
• W2416366909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4418459" @default.
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