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• W2418565557 abstract "ANG II arrests LLC-PK 1 cells in the G 1 phase of the cell cycle and induces hypertrophy, an effect mediated by induction of p27 Kip1 . We studied whether atrial natriuretic peptide (ANP) may modulate ANG II-induced hypertrophy and p27 Kip1 expression in tubular LLC-PK 1 cells. ANP, through its fragments 3—28and 4—27, prevented ANG II-induced cell cycle arrest. ANP inhibited >80% of ANG II-induced p27 Kip1 protein expression (Western blots). ANP stimulated expression of MKP-1, a phosphatase involved in dephosphorylation of p44/42 mitogen-activated protein (MAP) kinase, up to 12 h. ANP prevented the ANG II-mediated phosphorylation peak of MAP kinase after 12 h of stimulation. 8-Bromo-cGMP mimicked all the effects of ANP. Transfection with MKP-1 antisense, but not sense, oligonucleotides abolished the modifying role of ANP on ANG II-mediated cell cycle arrest . . The effect of ANP on ANG II-mediated hypertrophy of LLC-PK 1 cells is regulated on the level of MAP kinase phosphorylation, a key step in the induction of p27 Kip1 . Although ANP and ANG II both stimulate generation of reactive oxygen species, ANP additionally induces expression of MKP-1, leading to interference with ANG II-mediated MAP kinase phosphorylation." @default.
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• W2418565557 date "2001-07-01" @default.
• W2418565557 modified "2023-10-16" @default.
• W2418565557 title "Atrial natriuretic peptide attenuates ANG II-induced hypertrophy of renal tubular cells" @default.
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• W2418565557 doi "https://doi.org/10.1152/ajprenal.2001.281.1.f81" @default.
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