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• W2428660131 abstract "Pemphigoid is a chronic blistering autoimmune disease that is frequently seen in the elderly. It was grouped with other blistering diseases until it was differentiated from them on the basis of characteristic histology and natural history.1 Subsequent definition came from definitive immunopathologic features.2 Pemphigoid is a wide-spectrum disease that can affect the skin and all stratified squamous epithelial mucous membranes. In the literature it has been defined under various terms. A simple classification that is clinically relevant and has important ramification and utilization in management and therapy is presented in Table 1. Generally, patients have predominantly cutaneous or mucous membrane involvement; however, patients with the generalized cutaneous variety can have mucous membrane involvement, and patients with cicatricial pemphigoid do have cutaneous manifestations.2 Separation into localized and generalized forms is quite helpful in planning and focusing on therapy but is not necessarily rigid or complete, and overlaps do occur. Bullous pemphigoid (BP) is a disease of the elderly. The great majority of patients are over 60 years of age at onset of the disease process. In one series, 77% of the patients were over 70,3 though it can rarely occur in adults less than 40 years of age.4 It has been reported in children, and this is dealt with in detail in Chapter 3. Before the age of 60 it appears that women are more frequently affected than men; nonetheless, when the age of onset is over 70, men are probably more frequently affected than women, and this predominance in men increases with each subsequent decade.5 The true incidence is unknown since pemphigoid is not a reportable disease. It is believed to be twice as common as pemphigus.6 In our opinion, it is much more common than that because there is a significant increase in the percentage of the American population that is now over 60 years of age. This trend is likely to continue, and it can be expected that a larger number of patients with bullous pemphigoid may be seen in the years ahead. Pemphigoid is known to occur worldwide. There is not racial predilection or increased susceptibility. Furthermore, there is no increased prevalence of any specific HLA phenotype.7,8" @default.
• W2428660131 created "2016-06-24" @default.
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• W2428660131 date "1987-01-01" @default.
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• W2428660131 title "Clinical features" @default.
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• W2428660131 doi "https://doi.org/10.1016/0738-081x(87)90043-5" @default.
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