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- W2474366905 abstract "Significance Mutations in the PI3K pathway are highly prevalent in cancers, and isoform-specific and pan-PI3K inhibitors have entered clinical trials in both solid and hematologic malignancies. The PI3K δ-specific inhibitor idelalisib (in combination with rituximab) was recently approved for the treatment of chronic lymphocytic leukemia. However, identifying tumor types and biological mechanisms that predict for response to PI3K inhibitors as single agents or in combination has been a challenge. Our data indicate that PI3K inhibitors induce DNA damage in tumors that have defects in DNA damage-repair pathways and that they do so by impairing the production of Rib phosphate and amino acids needed for deoxynucleotide synthesis." @default.
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- W2474366905 date "2016-07-08" @default.
- W2474366905 modified "2023-10-10" @default.
- W2474366905 title "Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion" @default.
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- W2474366905 doi "https://doi.org/10.1073/pnas.1522223113" @default.
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