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- W2498889609 abstract "In 1997, the American neurologist and biochemist Stanley B. Prusiner received the Nobel Prize in medicine for his discovery of ‘prions’ - a new biological principle of infection. Preceding this discovery lies a complicated history of the research on a number of neurodegenerative diseases, including the sheep disease scrapie. During the 1960s, research on scrapie revealed that the infectious agent had very unusual characteristics, and a variety of hypotheses regarding the principle of scrapie infection were advanced. However, not until the 1980s did a single hypothesis, Prusiner’s prion hypothesis — which is basically a protein-only hypothesis1 — succeed in attracting the attention of the majority of the scientific community. Interestingly, protein-only hypotheses had been advanced as early as the mid-1960s but without receiving any notable support from other scientists than those who had advanced them." @default.
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- W2498889609 date "2004-01-01" @default.
- W2498889609 modified "2023-10-16" @default.
- W2498889609 title "The Early History of the Protein-only Hypothesis: Scientific Change and Multidisciplinary Research" @default.
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- W2498889609 doi "https://doi.org/10.1057/9780230524392_2" @default.
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