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- W2512577309 endingPage "29" @default.
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- W2512577309 abstract "Horizontal gene transfer (HGT) is a driving force to the evolution of bacteria. The fast emergence of antimicrobial resistance reflects the ability of genetic adaptation of pathogens. Acinetobacter baumannii has emerged in the last few decades as an important opportunistic nosocomial pathogen, in part due to its high capacity of acquiring resistance to diverse antibiotic families, including to the so-called last line drugs such as carbapenems. The rampant selective pressure and genetic exchange of resistance genes hinder the effective treatment of resistant infections. A. baumannii uses all the resistance mechanisms to survive against carbapenems but production of carbapenemases are the major mechanism, which may act in synergy with others. A. baumannii appears to use all the mechanisms of gene dissemination. Beyond conjugation, the mostly reported recent studies point to natural transformation, transduction and outer membrane vesicles-mediated transfer as mechanisms that may play a role in carbapenemase determinants spread. Understanding the genetic mobilization of carbapenemase genes is paramount in preventing their dissemination. Here we review the carbapenemases found in A. baumannii and present an overview of the current knowledge of contributions of the various HGT mechanisms to the molecular epidemiology of carbapenem resistance in this relevant opportunistic pathogen." @default.
- W2512577309 created "2016-09-16" @default.
- W2512577309 creator A5021284604 @default.
- W2512577309 creator A5089395738 @default.
- W2512577309 date "2016-08-23" @default.
- W2512577309 modified "2023-09-30" @default.
- W2512577309 title "Insights on the Horizontal Gene Transfer of Carbapenemase Determinants in the Opportunistic Pathogen Acinetobacter baumannii" @default.
- W2512577309 cites W1482511717 @default.
- W2512577309 cites W1522929799 @default.
- W2512577309 cites W1759202011 @default.
- W2512577309 cites W1785819724 @default.
- W2512577309 cites W1796585208 @default.
- W2512577309 cites W1816147328 @default.
- W2512577309 cites W1845997799 @default.
- W2512577309 cites W1856140562 @default.
- W2512577309 cites W1863371690 @default.
- W2512577309 cites W1902535075 @default.
- W2512577309 cites W1903465986 @default.
- W2512577309 cites W1911549946 @default.
- W2512577309 cites W1911845649 @default.
- W2512577309 cites W1920890130 @default.
- W2512577309 cites W1923791809 @default.
- W2512577309 cites W1938651701 @default.
- W2512577309 cites W1957607863 @default.
- W2512577309 cites W1968068587 @default.
- W2512577309 cites W1970559386 @default.
- W2512577309 cites W1976352129 @default.
- W2512577309 cites W1977893904 @default.
- W2512577309 cites W1978988490 @default.
- W2512577309 cites W1984809228 @default.
- W2512577309 cites W1984967453 @default.
- W2512577309 cites W1986021215 @default.
- W2512577309 cites W1986487208 @default.
- W2512577309 cites W1988051787 @default.
- W2512577309 cites W1989648531 @default.
- W2512577309 cites W1994519842 @default.
- W2512577309 cites W1995085773 @default.
- W2512577309 cites W1996647875 @default.
- W2512577309 cites W1998468520 @default.
- W2512577309 cites W1999203150 @default.
- W2512577309 cites W1999265131 @default.
- W2512577309 cites W1999397178 @default.
- W2512577309 cites W2003111323 @default.
- W2512577309 cites W2006881751 @default.
- W2512577309 cites W2008394826 @default.
- W2512577309 cites W2008858932 @default.
- W2512577309 cites W2009089119 @default.
- W2512577309 cites W2011080054 @default.
- W2512577309 cites W2013485399 @default.
- W2512577309 cites W2014477899 @default.
- W2512577309 cites W2015163098 @default.
- W2512577309 cites W2019577872 @default.
- W2512577309 cites W2019615869 @default.
- W2512577309 cites W2020956321 @default.
- W2512577309 cites W2023058046 @default.
- W2512577309 cites W2024516268 @default.
- W2512577309 cites W2027339965 @default.
- W2512577309 cites W2029071234 @default.
- W2512577309 cites W2034359054 @default.
- W2512577309 cites W2037248614 @default.
- W2512577309 cites W2044051664 @default.
- W2512577309 cites W2045109873 @default.
- W2512577309 cites W2045862779 @default.
- W2512577309 cites W2050783903 @default.
- W2512577309 cites W2055979131 @default.
- W2512577309 cites W2057665284 @default.
- W2512577309 cites W2057684478 @default.
- W2512577309 cites W2058284256 @default.
- W2512577309 cites W2059330749 @default.
- W2512577309 cites W2060413674 @default.
- W2512577309 cites W2061092522 @default.
- W2512577309 cites W2061911055 @default.
- W2512577309 cites W2067470076 @default.
- W2512577309 cites W2069200382 @default.
- W2512577309 cites W2071009276 @default.
- W2512577309 cites W2072455655 @default.
- W2512577309 cites W2079142303 @default.
- W2512577309 cites W2079236184 @default.
- W2512577309 cites W2087184445 @default.
- W2512577309 cites W2091957867 @default.
- W2512577309 cites W2093644984 @default.
- W2512577309 cites W2094014355 @default.
- W2512577309 cites W2096553560 @default.
- W2512577309 cites W2096643825 @default.
- W2512577309 cites W2097378554 @default.
- W2512577309 cites W2098626851 @default.
- W2512577309 cites W2098688781 @default.
- W2512577309 cites W2101567700 @default.
- W2512577309 cites W2102697187 @default.
- W2512577309 cites W2104186571 @default.
- W2512577309 cites W2105393577 @default.
- W2512577309 cites W2105506586 @default.
- W2512577309 cites W2107458162 @default.
- W2512577309 cites W2110256580 @default.
- W2512577309 cites W2111123862 @default.
- W2512577309 cites W2111426588 @default.
- W2512577309 cites W2114231217 @default.
- W2512577309 cites W2114466566 @default.