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• W2518529034 abstract "Some new phosphonoester-linked oligomers, stabilized analogues of the corresponding phosphate-bridged oligomers of Neisseria meningitidis A (MenA) capsular polysaccharide (CPS), were conjugated to human serum albumin (HSA), as a protein carrier model, and studied for immunological activities. We determined (i) in vitro, their biocompatibility (CAM test) and activity in inducing both T cell proliferation (CFSE method) and IL-2 release (ELISA), and (ii) in vivo, their ability to stimulate specific IgG antibody production (ELISA). All HSA-conjugated compounds induce T cell proliferation (40% of proliferation at 102 μM), whereas only the phosphonodisaccharide was effective (28% of proliferation at 102 μM) among the unconjugated forms. IL-2 release confirmed these results. In addition, the HSA-conjugated showed in vivo the capacity of eliciting the production of specific IgG antibodies. In conclusion, we obtained novel biocompatible, water-stable, and immunoactive MenA CPS analogues. A short disaccharide fragment showed the unusual behavior of triggering T cell proliferation in vitro." @default.
• W2518529034 created "2016-09-16" @default.
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• W2518529034 date "2015-08-17" @default.
• W2518529034 modified "2023-09-26" @default.
• W2518529034 title "A Synthetic Disaccharide Analogue from <i>Neisseria meningitidis</i> A Capsular Polysaccharide Stimulates Immune Cell Responses and Induces Immunoglobulin G (IgG) Production in Mice When Protein-Conjugated" @default.
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• W2518529034 doi "https://doi.org/10.1021/acsinfecdis.5b00071" @default.
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