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• W2530014101 abstract "Nano-carriers, especially lipid nanoparticles have been used widely in “a good manner”, for instance in the treatment of cancer, by enhancing the targetability and reducing required dose. Here in the contrary, we presented a new possibility: nanoDEN, a nanoparticle-packed “bad guy”, which is more effective and efficient in generating liver tumor in mice. We have shown that nanoDEN, same as diethylnitrosamine (DEN), induced overexpression of multiple pivotal factors (including COX-2, β-catenin and PCNA) during oncogenesis. Moreover, nanoDEN increased the apoptosis of liver cells compared with DEN alone. This apoptotic effect of nanoDEN is more efficient on normal cells than on cancer cells. Taken into consideration the fact that there are endogenous nanoparticles naturally formed inside our body, our research enlarged our views of all the aspects of oncogenic chemicals, while also established a better method of producing animal model of liver cancer, which has future investigational and therapeutical potential." @default.
• W2530014101 created "2016-10-21" @default.
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• W2530014101 date "2017-02-01" @default.
• W2530014101 modified "2023-10-01" @default.
• W2530014101 title "The dark side of “the force” – lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice" @default.
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• W2530014101 doi "https://doi.org/10.1016/j.nano.2016.09.017" @default.
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