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- W2536618353 abstract "Objective Proton magnetic resonance spectroscopy ( 1 H-MRS) was used to evaluate metabolic changes in the dorsolateral prefrontal cortex (DLPFC) in patients with obsessive–compulsive disorder (OCD). Methods In total, 14 OCD patients (mean age 28.9±7.2 years) and 14 healthy controls (mean age 32.6±7.1 years) with no history of neurological and psychiatric illness participated in this study. Brain metabolite concentrations were measured from a localised voxel on the right DLPFC using a 3-Tesla 1 H-MRS. Results The metabolic concentration of myo -inositol in patients with OCD increased significantly by 52% compared with the healthy controls, whereas glutamine/glutamate was decreased by 11%. However, there were no significant differences in N -acetylaspartate, choline, lactate and lipid between the two groups. Conclusion These findings would be helpful to understand the pathophysiology of OCD associated with the brain metabolic abnormalities in the right DLPFC." @default.
- W2536618353 created "2016-10-28" @default.
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- W2536618353 date "2016-10-17" @default.
- W2536618353 modified "2023-09-25" @default.
- W2536618353 title "Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive–compulsive disorder: proton magnetic resonance spectroscopy" @default.
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- W2536618353 doi "https://doi.org/10.1017/neu.2016.48" @default.
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