FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549810297> ?p ?o ?g. }

• W2549810297 endingPage "1666" @default.
• W2549810297 startingPage "1659" @default.
• W2549810297 abstract "Inflammation-modulating cytokine profile and lipid interaction in HIV-related risk factors for cardiovascular diseases Elizabeth Gori,1,2 Takafira Mduluza,3,4 Mudavanhu Nyagura,2 Babill Stray-Pedersen,5 Zvenyika Alfred Gomo1 1Chemical Pathology Department, College of Health Sciences, 2Preclinical Veterinary Studies Department, Faculty of Veterinary Sciences, 3Biochemistry Department, University of Zimbabwe, Harare, Zimbabwe; 4School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; 5Institute of Clinical Medicine, University in Oslo, Oslo University Hospital, Oslo, Norway Abstract: HIV infection and antiretroviral therapy (ART) are associated with changes in plasma levels of lipoproteins, thus posing the risk of cardiovascular complications in infected individuals. The alteration in plasma lipoprotein levels results from dysregulation of inflammation-modulating cytokines that control lipid metabolism. Little is understood regarding the relationship between the cytokines and serum lipid levels, which have been reported to be altered in adults receiving ART. The objective of this study was to describe the profiles of inflammation-modulating cytokines and their relationship to lipids as cardiovascular disease (CVD) risk factors in HIV infection. This observational cross-sectional study measured plasma levels of interleukin (IL)-10, tumor necrosis factor-alpha (TNF)-α, IL-4, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-c) in HIV-infected and uninfected adults. A total of 219 HIV-infected participants were enrolled from an HIV treatment center; of them, 187 were receiving ART and 32 were ART naïve, while 65 were HIV-uninfected blood donors. HIV-infected individuals had higher levels of IL-10 (HIV-infected ART-naïve [P=0.0024] and ART-receiving [P=0.033]) than their uninfected counterparts. ART-naïve subjects had significantly higher plasma levels of IL-10 than ART-receiving subjects (P=0.0014). No significant difference was observed in plasma levels of IL-4 and TNF-α across the three groups. Regarding plasma lipoproteins, HDL-c levels were reduced in HIV ART-naïve (P=0.002) and ART-receiving (P=0.015) subjects compared to HIV-uninfected subjects. Similarly, TC levels were lower in the HIV-infected than in the HIV-uninfected group regardless of whether the patients were undergoing ART or not (P<0.001). IL-10 levels correlated with TC levels in the HIV-uninfected group but not in the HIV-infected groups. Levels of HDL-c were reduced, while IL-10 plasma concentrations were elevated in HIV-infected individuals. A correlation observed in HIV-uninfected individuals between anti-inflammatory cytokine IL-10 and TC was lost in HIV-infected individuals. Clinical significance of these differences needs to be ascertained with respect to HIV-related CVD risk. Keywords: HIV, inflammation, cytokines, antiretroviral therapy, cardiovascular disease risk" @default.
• W2549810297 created "2016-11-30" @default.
• W2549810297 creator A5008535125 @default.
• W2549810297 creator A5040124117 @default.
• W2549810297 creator A5053764399 @default.
• W2549810297 creator A5064692488 @default.
• W2549810297 creator A5078263073 @default.
• W2549810297 date "2016-11-01" @default.
• W2549810297 modified "2023-09-25" @default.
• W2549810297 title "Inflammation-modulating cytokine profile and lipid interaction in HIV-related risk factors for cardiovascular diseases" @default.
• W2549810297 cites W172055262 @default.
• W2549810297 cites W1770527928 @default.
• W2549810297 cites W1788946230 @default.
• W2549810297 cites W1879288376 @default.
• W2549810297 cites W1975387480 @default.
• W2549810297 cites W1979151464 @default.
• W2549810297 cites W1979185358 @default.
• W2549810297 cites W1984871995 @default.
• W2549810297 cites W1994469981 @default.
• W2549810297 cites W1995915620 @default.
• W2549810297 cites W1996173037 @default.
• W2549810297 cites W2000226216 @default.
• W2549810297 cites W2019114283 @default.
• W2549810297 cites W2031357610 @default.
• W2549810297 cites W2034783317 @default.
• W2549810297 cites W2043713711 @default.
• W2549810297 cites W2054641701 @default.
• W2549810297 cites W2055406349 @default.
• W2549810297 cites W2062012447 @default.
• W2549810297 cites W2069020838 @default.
• W2549810297 cites W2073816163 @default.
• W2549810297 cites W2088425339 @default.
• W2549810297 cites W2088855630 @default.
• W2549810297 cites W2093327629 @default.
• W2549810297 cites W2095620419 @default.
• W2549810297 cites W2104937096 @default.
• W2549810297 cites W2107548027 @default.
• W2549810297 cites W2111966641 @default.
• W2549810297 cites W2116512634 @default.
• W2549810297 cites W2118944665 @default.
• W2549810297 cites W2139508877 @default.
• W2549810297 cites W2140725044 @default.
• W2549810297 cites W2142748172 @default.
• W2549810297 cites W2150129064 @default.
• W2549810297 cites W2163400856 @default.
• W2549810297 cites W2237288554 @default.
• W2549810297 cites W2258905495 @default.
• W2549810297 cites W2408836370 @default.
• W2549810297 cites W4296391115 @default.
• W2549810297 doi "https://doi.org/10.2147/tcrm.s117980" @default.
• W2549810297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5113933" @default.
• W2549810297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27956833" @default.
• W2549810297 hasPublicationYear "2016" @default.
• W2549810297 type Work @default.
• W2549810297 sameAs 2549810297 @default.
• W2549810297 citedByCount "12" @default.
• W2549810297 countsByYear W25498102972017 @default.
• W2549810297 countsByYear W25498102972018 @default.
• W2549810297 countsByYear W25498102972020 @default.
• W2549810297 countsByYear W25498102972021 @default.
• W2549810297 countsByYear W25498102972022 @default.
• W2549810297 countsByYear W25498102972023 @default.
• W2549810297 crossrefType "journal-article" @default.
• W2549810297 hasAuthorship W2549810297A5008535125 @default.
• W2549810297 hasAuthorship W2549810297A5040124117 @default.
• W2549810297 hasAuthorship W2549810297A5053764399 @default.
• W2549810297 hasAuthorship W2549810297A5064692488 @default.
• W2549810297 hasAuthorship W2549810297A5078263073 @default.
• W2549810297 hasBestOaLocation W25498102971 @default.
• W2549810297 hasConcept C126322002 @default.
• W2549810297 hasConcept C17991360 @default.
• W2549810297 hasConcept C203014093 @default.
• W2549810297 hasConcept C23131810 @default.
• W2549810297 hasConcept C2776914184 @default.
• W2549810297 hasConcept C2778163477 @default.
• W2549810297 hasConcept C2778270857 @default.
• W2549810297 hasConcept C2778690821 @default.
• W2549810297 hasConcept C2779134260 @default.
• W2549810297 hasConcept C3013748606 @default.
• W2549810297 hasConcept C42407357 @default.
• W2549810297 hasConcept C4733338 @default.
• W2549810297 hasConcept C50440223 @default.
• W2549810297 hasConcept C71924100 @default.
• W2549810297 hasConceptScore W2549810297C126322002 @default.
• W2549810297 hasConceptScore W2549810297C17991360 @default.
• W2549810297 hasConceptScore W2549810297C203014093 @default.
• W2549810297 hasConceptScore W2549810297C23131810 @default.
• W2549810297 hasConceptScore W2549810297C2776914184 @default.
• W2549810297 hasConceptScore W2549810297C2778163477 @default.
• W2549810297 hasConceptScore W2549810297C2778270857 @default.
• W2549810297 hasConceptScore W2549810297C2778690821 @default.
• W2549810297 hasConceptScore W2549810297C2779134260 @default.
• W2549810297 hasConceptScore W2549810297C3013748606 @default.
• W2549810297 hasConceptScore W2549810297C42407357 @default.
• W2549810297 hasConceptScore W2549810297C4733338 @default.
• W2549810297 hasConceptScore W2549810297C50440223 @default.
• W2549810297 hasConceptScore W2549810297C71924100 @default.
• W2549810297 hasLocation W25498102971 @default.

• next