FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2559867400> ?p ?o ?g. }

• W2559867400 endingPage "e0167828" @default.
• W2559867400 startingPage "e0167828" @default.
• W2559867400 abstract "Retinal ischemia/reperfusion injury is a common feature of various retinal diseases such as glaucoma and diabetic retinopathy. Lutein, a potent anti-oxidant, is used to improve visual function in patients with age-related macular degeneration (AMD). Lutein attenuates apoptosis, oxidative stress and inflammation in animal models of acute retinal ischemia/hypoxia. Here, we further show that lutein improved Műller cell viability and enhanced cell survival upon hypoxia-induced cell death through regulation of intrinsic apoptotic pathway. Moreover, autophagy was activated upon treatment of cobalt (II) chloride, indicating that hypoxic injury not only triggered apoptosis but also autophagy in our in vitro model. Most importantly, we report for the first time that lutein treatment suppressed autophagosome formation after hypoxic insult and lutein administration could inhibit autophagic event after activation of autophagy by a pharmacological approach (rapamycin). Taken together, lutein may have a beneficial role in enhancing glial cell survival after hypoxic injury through regulating both apoptosis and autophagy." @default.
• W2559867400 created "2016-12-16" @default.
• W2559867400 creator A5069372541 @default.
• W2559867400 creator A5081444359 @default.
• W2559867400 creator A5087698754 @default.
• W2559867400 date "2016-12-09" @default.
• W2559867400 modified "2023-10-11" @default.
• W2559867400 title "Lutein Attenuates Both Apoptosis and Autophagy upon Cobalt (II) Chloride-Induced Hypoxia in Rat Műller Cells" @default.
• W2559867400 cites W100581730 @default.
• W2559867400 cites W101209234 @default.
• W2559867400 cites W1197553475 @default.
• W2559867400 cites W1220992234 @default.
• W2559867400 cites W1523693806 @default.
• W2559867400 cites W1578199863 @default.
• W2559867400 cites W173937341 @default.
• W2559867400 cites W1965194456 @default.
• W2559867400 cites W1970637701 @default.
• W2559867400 cites W1972748028 @default.
• W2559867400 cites W1975774056 @default.
• W2559867400 cites W1976869962 @default.
• W2559867400 cites W1977767269 @default.
• W2559867400 cites W1978932724 @default.
• W2559867400 cites W1979187732 @default.
• W2559867400 cites W1985070317 @default.
• W2559867400 cites W1987566410 @default.
• W2559867400 cites W1989874847 @default.
• W2559867400 cites W1994148925 @default.
• W2559867400 cites W1994823455 @default.
• W2559867400 cites W1995569466 @default.
• W2559867400 cites W1999477136 @default.
• W2559867400 cites W2000319689 @default.
• W2559867400 cites W2001853014 @default.
• W2559867400 cites W2007448480 @default.
• W2559867400 cites W2012653688 @default.
• W2559867400 cites W2018544336 @default.
• W2559867400 cites W2019448748 @default.
• W2559867400 cites W2035477351 @default.
• W2559867400 cites W2041546298 @default.
• W2559867400 cites W2042212286 @default.
• W2559867400 cites W2051276620 @default.
• W2559867400 cites W2053098204 @default.
• W2559867400 cites W2055823135 @default.
• W2559867400 cites W2059593140 @default.
• W2559867400 cites W2060787577 @default.
• W2559867400 cites W2065152591 @default.
• W2559867400 cites W2066208534 @default.
• W2559867400 cites W2066241164 @default.
• W2559867400 cites W2067328080 @default.
• W2559867400 cites W2070181056 @default.
• W2559867400 cites W2080816502 @default.
• W2559867400 cites W2083965168 @default.
• W2559867400 cites W2089183158 @default.
• W2559867400 cites W2091988248 @default.
• W2559867400 cites W2093195138 @default.
• W2559867400 cites W2094924391 @default.
• W2559867400 cites W2095568065 @default.
• W2559867400 cites W2102758832 @default.
• W2559867400 cites W2102950775 @default.
• W2559867400 cites W2104863592 @default.
• W2559867400 cites W2108924026 @default.
• W2559867400 cites W2109045394 @default.
• W2559867400 cites W2123957943 @default.
• W2559867400 cites W2132658045 @default.
• W2559867400 cites W2143112776 @default.
• W2559867400 cites W2150363952 @default.
• W2559867400 cites W2154666720 @default.
• W2559867400 cites W2155003672 @default.
• W2559867400 cites W2164778558 @default.
• W2559867400 cites W2168102018 @default.
• W2559867400 cites W2743254891 @default.
• W2559867400 cites W59883231 @default.
• W2559867400 doi "https://doi.org/10.1371/journal.pone.0167828" @default.
• W2559867400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5148028" @default.
• W2559867400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27936094" @default.
• W2559867400 hasPublicationYear "2016" @default.
• W2559867400 type Work @default.
• W2559867400 sameAs 2559867400 @default.
• W2559867400 citedByCount "41" @default.
• W2559867400 countsByYear W25598674002017 @default.
• W2559867400 countsByYear W25598674002018 @default.
• W2559867400 countsByYear W25598674002019 @default.
• W2559867400 countsByYear W25598674002020 @default.
• W2559867400 countsByYear W25598674002021 @default.
• W2559867400 countsByYear W25598674002022 @default.
• W2559867400 countsByYear W25598674002023 @default.
• W2559867400 crossrefType "journal-article" @default.
• W2559867400 hasAuthorship W2559867400A5069372541 @default.
• W2559867400 hasAuthorship W2559867400A5081444359 @default.
• W2559867400 hasAuthorship W2559867400A5087698754 @default.
• W2559867400 hasBestOaLocation W25598674001 @default.
• W2559867400 hasConcept C134018914 @default.
• W2559867400 hasConcept C178790620 @default.
• W2559867400 hasConcept C185592680 @default.
• W2559867400 hasConcept C190283241 @default.
• W2559867400 hasConcept C203522944 @default.
• W2559867400 hasConcept C2776151105 @default.
• W2559867400 hasConcept C2778411929 @default.
• W2559867400 hasConcept C2780827179 @default.

• next