FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567609478> ?p ?o ?g. }

• W2567609478 endingPage "561" @default.
• W2567609478 startingPage "555" @default.
• W2567609478 abstract "The study manifests the immunoadjuvant potential of saponin rich fraction from Asparagus racemosus in terms of cellular and humoral immune response that can be exploited against microbial infections. Asparagus racemosus (AR) has been attributed as an adaptogen and rasayana in traditional medication systems for enhancing the host defence mechanism. Spectrophotometric and HPTLC analysis ensured the presence of saponins. The saponin rich fractions were tested for immunoadjuvant property in ovalbumin immunised mice for the humoral response, quantified in terms of prolonged antibody production upto a duration of 56 days. Proinflammatory cytokines (IL-6 and TNF) were estimated for the cellular immune response in LPS stimulated primary murine macrophages. The safety evaluation in terms of cytotoxicity and allergic response has also been evaluated through in-vitro (MTT) and in-vivo (IgE) respectively. ARS significantly inhibited the pro-inflammatory cytokines, in LPS stimulated murine macrophages with no intrinsic cytotoxicity. The significant increase in IgG production infers the utility of ARS for prolonged humoral response. Further, the antigen specific response of IL-12 at early stage and IgE titres also suggests the generation of cellular immune response and low allergic reaction respectively, as compared to conventional adjuvants. IL-6 and TNF fluctuations in LPS stimulated and non-stimulated macrophages along with IgG and IL-12 also confirmed the Th1/Th2 modulating effect of ARS. The study indicates potential effect of ARS as an adjuvant for the stimulation of cellular immune response in addition to generating a sustained adaptive response without any adverse effects paving way for further validation with pathogenic organisms." @default.
• W2567609478 created "2017-01-06" @default.
• W2567609478 creator A5004256755 @default.
• W2567609478 creator A5006318210 @default.
• W2567609478 creator A5015685802 @default.
• W2567609478 creator A5030309063 @default.
• W2567609478 creator A5054911906 @default.
• W2567609478 creator A5081450323 @default.
• W2567609478 creator A5085349807 @default.
• W2567609478 date "2017-02-01" @default.
• W2567609478 modified "2023-10-16" @default.
• W2567609478 title "Adjuvant effect of Asparagus racemosus Willd. derived saponins in antibody production, allergic response and pro-inflammatory cytokine modulation" @default.
• W2567609478 cites W1574661275 @default.
• W2567609478 cites W1976382588 @default.
• W2567609478 cites W1987016144 @default.
• W2567609478 cites W1988945757 @default.
• W2567609478 cites W1995808454 @default.
• W2567609478 cites W2011302465 @default.
• W2567609478 cites W2013748537 @default.
• W2567609478 cites W2039215765 @default.
• W2567609478 cites W2043567210 @default.
• W2567609478 cites W2048371420 @default.
• W2567609478 cites W2059537808 @default.
• W2567609478 cites W2071982065 @default.
• W2567609478 cites W2076654968 @default.
• W2567609478 cites W2090698640 @default.
• W2567609478 cites W2161836547 @default.
• W2567609478 doi "https://doi.org/10.1016/j.biopha.2016.11.087" @default.
• W2567609478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28024292" @default.
• W2567609478 hasPublicationYear "2017" @default.
• W2567609478 type Work @default.
• W2567609478 sameAs 2567609478 @default.
• W2567609478 citedByCount "13" @default.
• W2567609478 countsByYear W25676094782017 @default.
• W2567609478 countsByYear W25676094782018 @default.
• W2567609478 countsByYear W25676094782019 @default.
• W2567609478 countsByYear W25676094782020 @default.
• W2567609478 countsByYear W25676094782021 @default.
• W2567609478 countsByYear W25676094782022 @default.
• W2567609478 countsByYear W25676094782023 @default.
• W2567609478 crossrefType "journal-article" @default.
• W2567609478 hasAuthorship W2567609478A5004256755 @default.
• W2567609478 hasAuthorship W2567609478A5006318210 @default.
• W2567609478 hasAuthorship W2567609478A5015685802 @default.
• W2567609478 hasAuthorship W2567609478A5030309063 @default.
• W2567609478 hasAuthorship W2567609478A5054911906 @default.
• W2567609478 hasAuthorship W2567609478A5081450323 @default.
• W2567609478 hasAuthorship W2567609478A5085349807 @default.
• W2567609478 hasConcept C109316439 @default.
• W2567609478 hasConcept C141105273 @default.
• W2567609478 hasConcept C142724271 @default.
• W2567609478 hasConcept C159654299 @default.
• W2567609478 hasConcept C164027704 @default.
• W2567609478 hasConcept C185592680 @default.
• W2567609478 hasConcept C202751555 @default.
• W2567609478 hasConcept C203014093 @default.
• W2567609478 hasConcept C204787440 @default.
• W2567609478 hasConcept C2776914184 @default.
• W2567609478 hasConcept C2776946954 @default.
• W2567609478 hasConcept C2776953665 @default.
• W2567609478 hasConcept C2777863537 @default.
• W2567609478 hasConcept C2778223594 @default.
• W2567609478 hasConcept C2778564307 @default.
• W2567609478 hasConcept C2778690821 @default.
• W2567609478 hasConcept C2778754761 @default.
• W2567609478 hasConcept C2779158651 @default.
• W2567609478 hasConcept C2909935589 @default.
• W2567609478 hasConcept C55493867 @default.
• W2567609478 hasConcept C556039675 @default.
• W2567609478 hasConcept C71924100 @default.
• W2567609478 hasConcept C86803240 @default.
• W2567609478 hasConcept C8891405 @default.
• W2567609478 hasConcept C98274493 @default.
• W2567609478 hasConceptScore W2567609478C109316439 @default.
• W2567609478 hasConceptScore W2567609478C141105273 @default.
• W2567609478 hasConceptScore W2567609478C142724271 @default.
• W2567609478 hasConceptScore W2567609478C159654299 @default.
• W2567609478 hasConceptScore W2567609478C164027704 @default.
• W2567609478 hasConceptScore W2567609478C185592680 @default.
• W2567609478 hasConceptScore W2567609478C202751555 @default.
• W2567609478 hasConceptScore W2567609478C203014093 @default.
• W2567609478 hasConceptScore W2567609478C204787440 @default.
• W2567609478 hasConceptScore W2567609478C2776914184 @default.
• W2567609478 hasConceptScore W2567609478C2776946954 @default.
• W2567609478 hasConceptScore W2567609478C2776953665 @default.
• W2567609478 hasConceptScore W2567609478C2777863537 @default.
• W2567609478 hasConceptScore W2567609478C2778223594 @default.
• W2567609478 hasConceptScore W2567609478C2778564307 @default.
• W2567609478 hasConceptScore W2567609478C2778690821 @default.
• W2567609478 hasConceptScore W2567609478C2778754761 @default.
• W2567609478 hasConceptScore W2567609478C2779158651 @default.
• W2567609478 hasConceptScore W2567609478C2909935589 @default.
• W2567609478 hasConceptScore W2567609478C55493867 @default.
• W2567609478 hasConceptScore W2567609478C556039675 @default.
• W2567609478 hasConceptScore W2567609478C71924100 @default.
• W2567609478 hasConceptScore W2567609478C86803240 @default.
• W2567609478 hasConceptScore W2567609478C8891405 @default.
• W2567609478 hasConceptScore W2567609478C98274493 @default.

• next