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• W2570295517 abstract "Gene regulatory networks (GRNs) play an important role in cellular systems and are important for understanding biological processes. Many algorithms have been developed to infer the GRNs. However, most algorithms only pay attention to the gene expression data but do not consider the topology information in their inference process, while incorporating this information can partially compensate for the lack of reliable expression data. Here we develop a Bayesian group lasso with spike and slab priors to perform gene selection and estimation for nonparametric models. B-spline basis functions are used to capture the nonlinear relationships flexibly and penalties are used to avoid overfitting. Further, we incorporate the topology information into the Bayesian method as a prior. We present the application of our method on DREAM3 and DREAM4 datasets and two real biological datasets. The results show that our method performs better than existing methods and the topology information prior can improve the result." @default.
• W2570295517 created "2017-01-13" @default.
• W2570295517 creator A5074144985 @default.
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• W2570295517 date "2017-01-01" @default.
• W2570295517 modified "2023-10-16" @default.
• W2570295517 title "Inference of Gene Regulatory Networks Using Bayesian Nonparametric Regression and Topology Information" @default.
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• W2570295517 doi "https://doi.org/10.1155/2017/8307530" @default.
• W2570295517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5241943" @default.
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