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- W2573345698 abstract "c-Jun is an activating protein 1 (AP-1) transcription factor and implicated in many aspects of cellular functions, but its exact role in the regulation of early intestinal epithelial restitution after injury remains largely unknown. Phospholipase C-γ1 (PLCγ1) catalyzes hydrolysis of phosphatidylinositol 4,5 biphosphate into the second messenger diacylglycerol and inositol 1,4,5 triphosphate, coordinates Ca 2+ store mobilization, and regulates cell migration and proliferation in response to stress. Here we reported that c-Jun upregulates PLCγ1 expression and enhances PLCγ1-induced Ca 2+ signaling, thus promoting intestinal epithelial restitution after wounding. Ectopically expressed c-Jun increased PLCγ1 expression at the transcription level, and this stimulation is mediated by directly interacting with AP-1 and CCAAT-enhancer-binding protein (C/EBP) binding sites that are located at the proximal region of the rat PLCγ1 promoter. Increased levels of PLCγ1 by c-Jun elevated cytosolic free Ca 2+ concentration and stimulated intestinal epithelial cell migration over the denuded area after wounding. The c-Jun-mediated PLCγ1/Ca 2+ signal also plays an important role in polyamine-induced cell migration after wounding because increased c-Jun rescued Ca 2+ influx and cell migration in polyamine-deficient cells. These findings indicate that c-Jun induces PLCγ1 expression transcriptionally and enhances rapid epithelial restitution after injury by activating Ca 2+ signal." @default.
- W2573345698 created "2017-01-26" @default.
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- W2573345698 date "2017-04-01" @default.
- W2573345698 modified "2023-10-18" @default.
- W2573345698 title "c-Jun enhances intestinal epithelial restitution after wounding by increasing phospholipase C-γ1 transcription" @default.
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- W2573345698 doi "https://doi.org/10.1152/ajpcell.00330.2016" @default.
- W2573345698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5407017" @default.
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