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• W2580528096 abstract "Single-cell RNA sequencing of preimplantation mouse embryos demonstrates that lack of paternal Xist leads to genome-wide transcriptional misregulation in the early blastocyst and a failure to activate the extraembryonic pathway. The long noncoding RNA Xist is expressed from only the paternal X chromosome in mouse preimplantation female embryos and mediates transcriptional silencing of that chromosome. In females, absence of Xist leads to postimplantation lethality. Here, through single-cell RNA sequencing of early preimplantation mouse embryos, we found that the initiation of imprinted X-chromosome inactivation absolutely requires Xist. Lack of paternal Xist leads to genome-wide transcriptional misregulation in the early blastocyst and to failure to activate the extraembryonic pathway that is essential for postimplantation development. We also demonstrate that the expression dynamics of X-linked genes depends on the strain and parent of origin as well as on the location along the X chromosome, particularly at the first 'entry' sites of Xist. This study demonstrates that dosage-compensation failure has an effect as early as the blastocyst stage and reveals genetic and epigenetic contributions to orchestrating transcriptional silencing of the X chromosome during early embryogenesis." @default.
• W2580528096 created "2017-02-03" @default.
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• W2580528096 date "2017-01-30" @default.
• W2580528096 modified "2023-10-13" @default.
• W2580528096 title "Xist-dependent imprinted X inactivation and the early developmental consequences of its failure" @default.
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• W2580528096 doi "https://doi.org/10.1038/nsmb.3365" @default.
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