FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594200423> ?p ?o ?g. }

• W2594200423 endingPage "576" @default.
• W2594200423 startingPage "565" @default.
• W2594200423 abstract "Abstract The Merkel disc is a main type of tactile end organ consisting of Merkel cells and Aβ‐afferent endings that responds to tactile stimulation with slowly adapting type 1 (SA1) afferent impulses. Our recent study has shown that Merkel discs in whisker hair follicles are serotonergic synapses using endogenous serotonin to transmit tactile signals from Merkel cells to Aβ‐afferent endings. In this study, we hypothesize that tactile sensitivity of Merkel discs can be modulated by chemical messengers. We tested this hypothesis by determining whether and how SA1 responses of mouse whisker hair follicles may be affected by exogenously applied chemical messengers. We found that SA1 responses were potentiated by serotonin at low concentration (10 μM) but almost completely occluded by serotonin at high concentration (2 mM). In contrast, SA1 responses were not significantly affected by ATP and its metabolically stable analog α,β‐methylene‐ATP, glutamate, γ‐aminobutyric acid (GABA), and histamine. SA1 responses were also not affected by antagonists for P2X receptors, ionotropic glutamate receptors, and ionotropic GABA and glycine receptors. Whole‐cell patch‐clamp recordings reconfirm the presence of both ionotropic and metabotropic 5‐HT receptors on afferent neurons and their terminals innervating whisker hair follicles. All whisker afferent neurons expressed hyperpolarization‐activated inward currents ( I h ), which are potentiated by serotonin through the activation of metabotropic 5‐HT receptors. Taken together, the findings substantiate the serotonergic mechanism of tactile transmission at Merkel discs and identify the involvement of I h currents in postsynaptic excitatory actions of serotonin. In addition, the findings do not favor any significant involvement of ATP, glutamate, histamine, GABA, or glycine in tactile transmission at the Merkel discs of whisker hair follicles. image" @default.
• W2594200423 created "2017-03-16" @default.
• W2594200423 creator A5000400882 @default.
• W2594200423 creator A5023888294 @default.
• W2594200423 creator A5034622125 @default.
• W2594200423 creator A5040415138 @default.
• W2594200423 creator A5045266132 @default.
• W2594200423 date "2017-03-27" @default.
• W2594200423 modified "2023-10-18" @default.
• W2594200423 title "Serotonergic transmission at Merkel discs: modulation by exogenously applied chemical messengers and involvement of<i>I</i>_hcurrents" @default.
• W2594200423 cites W1518104603 @default.
• W2594200423 cites W1531289420 @default.
• W2594200423 cites W1592755942 @default.
• W2594200423 cites W1675050582 @default.
• W2594200423 cites W1973466356 @default.
• W2594200423 cites W1990323943 @default.
• W2594200423 cites W1991540821 @default.
• W2594200423 cites W2013519188 @default.
• W2594200423 cites W2014001501 @default.
• W2594200423 cites W2035158250 @default.
• W2594200423 cites W2047012091 @default.
• W2594200423 cites W2052498348 @default.
• W2594200423 cites W2055774746 @default.
• W2594200423 cites W2064815668 @default.
• W2594200423 cites W2075715972 @default.
• W2594200423 cites W2077149536 @default.
• W2594200423 cites W2077894059 @default.
• W2594200423 cites W2092511662 @default.
• W2594200423 cites W2104381670 @default.
• W2594200423 cites W2107634021 @default.
• W2594200423 cites W2114625157 @default.
• W2594200423 cites W2118163741 @default.
• W2594200423 cites W2166918203 @default.
• W2594200423 cites W2410865764 @default.
• W2594200423 cites W2510304453 @default.
• W2594200423 cites W2560672679 @default.
• W2594200423 doi "https://doi.org/10.1111/jnc.14009" @default.
• W2594200423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6091886" @default.
• W2594200423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28267198" @default.
• W2594200423 hasPublicationYear "2017" @default.
• W2594200423 type Work @default.
• W2594200423 sameAs 2594200423 @default.
• W2594200423 citedByCount "10" @default.
• W2594200423 countsByYear W25942004232017 @default.
• W2594200423 countsByYear W25942004232018 @default.
• W2594200423 countsByYear W25942004232020 @default.
• W2594200423 countsByYear W25942004232021 @default.
• W2594200423 countsByYear W25942004232022 @default.
• W2594200423 crossrefType "journal-article" @default.
• W2594200423 hasAuthorship W2594200423A5000400882 @default.
• W2594200423 hasAuthorship W2594200423A5023888294 @default.
• W2594200423 hasAuthorship W2594200423A5034622125 @default.
• W2594200423 hasAuthorship W2594200423A5040415138 @default.
• W2594200423 hasAuthorship W2594200423A5045266132 @default.
• W2594200423 hasBestOaLocation W25942004231 @default.
• W2594200423 hasConcept C115955781 @default.
• W2594200423 hasConcept C134018914 @default.
• W2594200423 hasConcept C163235415 @default.
• W2594200423 hasConcept C169760540 @default.
• W2594200423 hasConcept C170493617 @default.
• W2594200423 hasConcept C185592680 @default.
• W2594200423 hasConcept C197341189 @default.
• W2594200423 hasConcept C200170125 @default.
• W2594200423 hasConcept C26702167 @default.
• W2594200423 hasConcept C2775864247 @default.
• W2594200423 hasConcept C2777546739 @default.
• W2594200423 hasConcept C2778342957 @default.
• W2594200423 hasConcept C2780291066 @default.
• W2594200423 hasConcept C37000724 @default.
• W2594200423 hasConcept C49051014 @default.
• W2594200423 hasConcept C53910766 @default.
• W2594200423 hasConcept C54355233 @default.
• W2594200423 hasConcept C55493867 @default.
• W2594200423 hasConcept C61174792 @default.
• W2594200423 hasConcept C86803240 @default.
• W2594200423 hasConceptScore W2594200423C115955781 @default.
• W2594200423 hasConceptScore W2594200423C134018914 @default.
• W2594200423 hasConceptScore W2594200423C163235415 @default.
• W2594200423 hasConceptScore W2594200423C169760540 @default.
• W2594200423 hasConceptScore W2594200423C170493617 @default.
• W2594200423 hasConceptScore W2594200423C185592680 @default.
• W2594200423 hasConceptScore W2594200423C197341189 @default.
• W2594200423 hasConceptScore W2594200423C200170125 @default.
• W2594200423 hasConceptScore W2594200423C26702167 @default.
• W2594200423 hasConceptScore W2594200423C2775864247 @default.
• W2594200423 hasConceptScore W2594200423C2777546739 @default.
• W2594200423 hasConceptScore W2594200423C2778342957 @default.
• W2594200423 hasConceptScore W2594200423C2780291066 @default.
• W2594200423 hasConceptScore W2594200423C37000724 @default.
• W2594200423 hasConceptScore W2594200423C49051014 @default.
• W2594200423 hasConceptScore W2594200423C53910766 @default.
• W2594200423 hasConceptScore W2594200423C54355233 @default.
• W2594200423 hasConceptScore W2594200423C55493867 @default.
• W2594200423 hasConceptScore W2594200423C61174792 @default.
• W2594200423 hasConceptScore W2594200423C86803240 @default.
• W2594200423 hasFunder F4320311855 @default.
• W2594200423 hasFunder F4320332161 @default.
• W2594200423 hasIssue "4" @default.

• next