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- W2601676887 endingPage "286" @default.
- W2601676887 startingPage "286" @default.
- W2601676887 abstract "We wanted to investigate the current knowledge on the impact of diet on anti-TNF response in inflammatory bowel diseases (IBD), to identify dietary factors that warrant further investigations in relation to anti-TNF treatment response, and, finally, to discuss potential strategies for such investigations. PubMed was searched using specified search terms. One small prospective study on diet and anti-TNF treatment in 56 patients with CD found similar remission rates after 56 weeks among 32 patients with good compliance that received concomitant enteral nutrition and 24 with poor compliance that had no dietary restrictions (78% versus 67%, p = 0.51). A meta-analysis of 295 patients found higher odds of achieving clinical remission and remaining in clinical remission among patients on combination therapy with specialised enteral nutrition and Infliximab (IFX) compared with IFX monotherapy (OR 2.73; 95% CI: 1.73–4.31, p < 0.01, OR 2.93; 95% CI: 1.66–5.17, p < 0.01, respectively). In conclusion, evidence-based knowledge on impact of diet on anti-TNF treatment response for clinical use is scarce. Here we propose a mechanism by which Western style diet high in meat and low in fibre may promote colonic inflammation and potentially impact treatment response to anti-TNF drugs. Further studies using hypothesis-driven and data-driven strategies in prospective observational, animal and interventional studies are warranted." @default.
- W2601676887 created "2017-04-07" @default.
- W2601676887 creator A5048781267 @default.
- W2601676887 creator A5061087463 @default.
- W2601676887 creator A5065163127 @default.
- W2601676887 date "2017-03-15" @default.
- W2601676887 modified "2023-09-26" @default.
- W2601676887 title "Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease" @default.
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