Matches in SemOpenAlex for { <https://semopenalex.org/work/W2643210008> ?p ?o ?g. }
- W2643210008 endingPage "1204" @default.
- W2643210008 startingPage "1197" @default.
- W2643210008 abstract "Cell death-inducing DFF45-like effector (CIDE) family proteins including Cidea, Cideb and Cidec/Fsp27 are expressed in many different tissues and are known as lipid droplet (LD)-and ER-associated proteins. Systematic analyses using genetically modified animal models have demonstrated that CIDE proteins play important roles in regulating various aspects of lipid homeostasis, including lipid storage, lipolysis and lipid secretion. Recent research in ours and other laboratories has revealed that CIDE proteins are crucial regulators of LD fusion and growth in the adipose tissue, liver, skin and mammary glands. CIDE-mediated LD fusion and growth is different from other membrane fusions in that it requires CIDE proteins to be enriched and clustered at the LD-LD contact sites (LDCS). The enriched CIDE proteins then allow the recruitment of other proteins to the LDCS and the formation of potential fusion pores. Neutral lipids in the smaller LDs of the contacted pair are transferred to the larger LDs, owing to the internal pressure difference, thus resulting in the fusion and growth of the LDs. This review summarizes the physiological roles of CIDE proteins in controlling lipid homeostasis, insulin sensitivity and the development of metabolic diseases including obesity, diabetes and fatty liver, with a particular focus on the role of CIDE proteins in controlling LD fusion and growth. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink." @default.
- W2643210008 created "2017-06-30" @default.
- W2643210008 creator A5011817044 @default.
- W2643210008 creator A5012038330 @default.
- W2643210008 creator A5013046599 @default.
- W2643210008 creator A5046937022 @default.
- W2643210008 creator A5054290452 @default.
- W2643210008 creator A5062621356 @default.
- W2643210008 creator A5071458554 @default.
- W2643210008 date "2017-10-01" @default.
- W2643210008 modified "2023-10-17" @default.
- W2643210008 title "Control of lipid droplet fusion and growth by CIDE family proteins" @default.
- W2643210008 cites W1552214119 @default.
- W2643210008 cites W1908352934 @default.
- W2643210008 cites W1966723744 @default.
- W2643210008 cites W1969702638 @default.
- W2643210008 cites W1970551770 @default.
- W2643210008 cites W1972461620 @default.
- W2643210008 cites W1973359170 @default.
- W2643210008 cites W1973488748 @default.
- W2643210008 cites W1975037124 @default.
- W2643210008 cites W1976292735 @default.
- W2643210008 cites W1978093763 @default.
- W2643210008 cites W1978317082 @default.
- W2643210008 cites W1979122274 @default.
- W2643210008 cites W1983754278 @default.
- W2643210008 cites W1987454590 @default.
- W2643210008 cites W1997238838 @default.
- W2643210008 cites W1998124940 @default.
- W2643210008 cites W1998949529 @default.
- W2643210008 cites W2000002411 @default.
- W2643210008 cites W2004934188 @default.
- W2643210008 cites W2007310375 @default.
- W2643210008 cites W2007663002 @default.
- W2643210008 cites W2013090884 @default.
- W2643210008 cites W2013927135 @default.
- W2643210008 cites W2014154105 @default.
- W2643210008 cites W2016795120 @default.
- W2643210008 cites W2017850421 @default.
- W2643210008 cites W2022756254 @default.
- W2643210008 cites W2025522799 @default.
- W2643210008 cites W2026497980 @default.
- W2643210008 cites W2030251861 @default.
- W2643210008 cites W2032905332 @default.
- W2643210008 cites W2033029728 @default.
- W2643210008 cites W2034781186 @default.
- W2643210008 cites W2043590275 @default.
- W2643210008 cites W2044575601 @default.
- W2643210008 cites W2059275312 @default.
- W2643210008 cites W2060125494 @default.
- W2643210008 cites W2063774526 @default.
- W2643210008 cites W2067170170 @default.
- W2643210008 cites W2073162567 @default.
- W2643210008 cites W2083293637 @default.
- W2643210008 cites W2084627907 @default.
- W2643210008 cites W2088545429 @default.
- W2643210008 cites W2091718432 @default.
- W2643210008 cites W2092454476 @default.
- W2643210008 cites W2096054485 @default.
- W2643210008 cites W2096757580 @default.
- W2643210008 cites W2098744542 @default.
- W2643210008 cites W2098940158 @default.
- W2643210008 cites W2099159895 @default.
- W2643210008 cites W2102390567 @default.
- W2643210008 cites W2103926074 @default.
- W2643210008 cites W2105172949 @default.
- W2643210008 cites W2111008058 @default.
- W2643210008 cites W2115876819 @default.
- W2643210008 cites W2117429772 @default.
- W2643210008 cites W2121105086 @default.
- W2643210008 cites W2121233961 @default.
- W2643210008 cites W2122486961 @default.
- W2643210008 cites W2123626585 @default.
- W2643210008 cites W2124349052 @default.
- W2643210008 cites W2128517000 @default.
- W2643210008 cites W2128565360 @default.
- W2643210008 cites W2130618859 @default.
- W2643210008 cites W2132468746 @default.
- W2643210008 cites W2136194082 @default.
- W2643210008 cites W2139611134 @default.
- W2643210008 cites W2143411269 @default.
- W2643210008 cites W2149039334 @default.
- W2643210008 cites W2152183245 @default.
- W2643210008 cites W2152399379 @default.
- W2643210008 cites W2156073539 @default.
- W2643210008 cites W2159905006 @default.
- W2643210008 cites W2165859364 @default.
- W2643210008 cites W2168356187 @default.
- W2643210008 cites W2169701998 @default.
- W2643210008 cites W2195516528 @default.
- W2643210008 cites W2274781935 @default.
- W2643210008 cites W2315409904 @default.
- W2643210008 cites W2461010831 @default.
- W2643210008 cites W2564557074 @default.
- W2643210008 cites W2592948596 @default.
- W2643210008 cites W4211197456 @default.
- W2643210008 cites W4243218473 @default.
- W2643210008 doi "https://doi.org/10.1016/j.bbalip.2017.06.009" @default.