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- W2751567609 abstract "Objectives: Lithium remains the oldest and most effective treatment for mood stabilisation in bipolar disorder (BD), even though at least half of patients are only partially responsive or do not respond. This study aimed to identify biomarkers associated with lithium response in BD, based on comparing RNA sequencing information derived from lymphoblastoid cell lines (LCLs) of lithium-responsive (LR) versus lithium non-responsive (LNR) BD patients, to assess gene expression variations that might bear on treatment outcome.Methods: RNA sequencing was carried out on 24 LCLs from female BD patients (12 LR and 12 LNR) followed by qPCR validation in two additional independent cohorts (41 and 17 BD patients, respectively).Results: Fifty-six genes showed nominal differential expression comparing LR and LNR (FC ≥ |1.3|, P ≤ 0.01). The differential expression of HDGFRP3 and ID2 was validated by qPCR in the independent cohorts.Conclusions: We observed higher expression levels of HDGFRP3 and ID2 in BD patients who favourably respond to lithium. Both of these genes are involved in neurogenesis, and HDGFRP3 has been suggested to be a neurotrophic factor. Additional studies in larger BD cohorts are needed to confirm the potential of HDGFRP3 and ID2 expression levels in blood cells as tentative favourable lithium response biomarkers." @default.
- W2751567609 created "2017-09-15" @default.
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- W2751567609 date "2017-09-22" @default.
- W2751567609 modified "2023-09-26" @default.
- W2751567609 title "RNA sequencing of bipolar disorder lymphoblastoid cell lines implicates the neurotrophic factor HRP-3 in lithium’s clinical efficacy" @default.
- W2751567609 cites W1457117615 @default.
- W2751567609 cites W1491088856 @default.
- W2751567609 cites W1494121093 @default.
- W2751567609 cites W1507115449 @default.
- W2751567609 cites W1645493186 @default.
- W2751567609 cites W1948469041 @default.
- W2751567609 cites W1963992683 @default.
- W2751567609 cites W1965205864 @default.
- W2751567609 cites W1967875000 @default.
- W2751567609 cites W1974498172 @default.
- W2751567609 cites W1974702488 @default.
- W2751567609 cites W1975174830 @default.
- W2751567609 cites W1986244535 @default.
- W2751567609 cites W1990027286 @default.
- W2751567609 cites W1995647101 @default.
- W2751567609 cites W1995653774 @default.
- W2751567609 cites W1996769229 @default.
- W2751567609 cites W2000766814 @default.
- W2751567609 cites W2004990148 @default.
- W2751567609 cites W2010132789 @default.
- W2751567609 cites W2014501754 @default.
- W2751567609 cites W2017446917 @default.
- W2751567609 cites W2018716777 @default.
- W2751567609 cites W2021227878 @default.
- W2751567609 cites W2025565849 @default.
- W2751567609 cites W2031200328 @default.
- W2751567609 cites W2031314964 @default.
- W2751567609 cites W2036112768 @default.
- W2751567609 cites W2036897871 @default.
- W2751567609 cites W2040354740 @default.
- W2751567609 cites W2041388941 @default.
- W2751567609 cites W2044954427 @default.
- W2751567609 cites W2046831392 @default.
- W2751567609 cites W2049165791 @default.
- W2751567609 cites W2050393284 @default.
- W2751567609 cites W2051814926 @default.
- W2751567609 cites W2063678473 @default.
- W2751567609 cites W2064063710 @default.
- W2751567609 cites W2069394934 @default.
- W2751567609 cites W2076389686 @default.
- W2751567609 cites W2094876017 @default.
- W2751567609 cites W2100239923 @default.
- W2751567609 cites W2105950992 @default.
- W2751567609 cites W2121408857 @default.
- W2751567609 cites W2123830992 @default.
- W2751567609 cites W2125412449 @default.
- W2751567609 cites W2128544662 @default.
- W2751567609 cites W2134526812 @default.
- W2751567609 cites W2135908086 @default.
- W2751567609 cites W2136422355 @default.
- W2751567609 cites W2137499573 @default.
- W2751567609 cites W2139372806 @default.
- W2751567609 cites W2140729960 @default.
- W2751567609 cites W2146512944 @default.
- W2751567609 cites W2149672258 @default.
- W2751567609 cites W2154881837 @default.
- W2751567609 cites W2156591457 @default.
- W2751567609 cites W2159898005 @default.
- W2751567609 cites W2160231011 @default.
- W2751567609 cites W2171466050 @default.
- W2751567609 cites W2179438025 @default.
- W2751567609 cites W2184290988 @default.
- W2751567609 cites W2223208500 @default.
- W2751567609 cites W2228309779 @default.
- W2751567609 cites W2262279506 @default.
- W2751567609 cites W2279935734 @default.
- W2751567609 cites W2397095296 @default.
- W2751567609 cites W2412099860 @default.
- W2751567609 cites W2415861471 @default.
- W2751567609 cites W2418579058 @default.
- W2751567609 cites W2468590741 @default.
- W2751567609 cites W2509192738 @default.
- W2751567609 cites W2528924905 @default.
- W2751567609 cites W2542225333 @default.
- W2751567609 cites W2553608151 @default.
- W2751567609 cites W2578062608 @default.
- W2751567609 cites W2584469054 @default.