FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2754304920> ?p ?o ?g. }

• W2754304920 endingPage "82955" @default.
• W2754304920 startingPage "82940" @default.
• W2754304920 abstract "The present study aimed to examine the associations between androgen receptor (AR) and forkhead box A1 (FOXA1) and to investigate clinicopathological features and survival according to both biomarker status in estrogen receptor (ER)-positive breast cancers using in vitro study, patient cohort data, and the cBioPortal for Cancer Genomics and Kaplan-Meier Plotter websites. Experiments using T47D and ZR75-1 demonstrated AR-overexpressing cell lines decreased in cell proliferation through downregulation of ER, but FOXA1 did not change. Knockdown of FOXA1 resulted in a significantly reduced cell viability. Patients with immunohistochemically AR(-)/FOXA1(-) tumor frequently showed node metastasis, high grade, and high Ki-67 proliferation, therefore, significantly worse survival in ER-positive disease. AR and FOXA1 mRNA levels were significantly higher in ER-positive than in ER-negative tumors and AR-low/FOXA1-low tumors showed high grade, frequent basal-like subtype and worse disease-free survival in ER-positive cancers of public gene dataset, similarly to patient cohort results. The Kaplan-Meier Plotter analysis independently validated patients with both low AR/FOXA1 tumor were significantly associated with worse relapse-free survival in ER-positive cancers. This study suggests that distinctive clinicopathological features according to AR and FOXA1 are determined and a lack of both biomarkers is an independent poor prognostic factor in ER-positive tumors." @default.
• W2754304920 created "2017-09-25" @default.
• W2754304920 creator A5012515136 @default.
• W2754304920 creator A5014605070 @default.
• W2754304920 creator A5019900739 @default.
• W2754304920 creator A5040393015 @default.
• W2754304920 creator A5040856605 @default.
• W2754304920 creator A5041491639 @default.
• W2754304920 date "2017-09-15" @default.
• W2754304920 modified "2023-10-12" @default.
• W2754304920 title "Lack of both androgen receptor and forkhead box A1 (FOXA1) expression is a poor prognostic factor in estrogen receptor-positive breast cancers" @default.
• W2754304920 cites W1129768243 @default.
• W2754304920 cites W1598969217 @default.
• W2754304920 cites W160192719 @default.
• W2754304920 cites W1904491573 @default.
• W2754304920 cites W1908864745 @default.
• W2754304920 cites W1976979840 @default.
• W2754304920 cites W1982378557 @default.
• W2754304920 cites W2002262418 @default.
• W2754304920 cites W2034032177 @default.
• W2754304920 cites W2037845535 @default.
• W2754304920 cites W2043152591 @default.
• W2754304920 cites W2045886863 @default.
• W2754304920 cites W2046389285 @default.
• W2754304920 cites W2048166083 @default.
• W2754304920 cites W2056242601 @default.
• W2754304920 cites W2074950916 @default.
• W2754304920 cites W2076283100 @default.
• W2754304920 cites W2078556843 @default.
• W2754304920 cites W2085934079 @default.
• W2754304920 cites W2086075883 @default.
• W2754304920 cites W2099744380 @default.
• W2754304920 cites W2101979288 @default.
• W2754304920 cites W2114843025 @default.
• W2754304920 cites W2117775530 @default.
• W2754304920 cites W2125407248 @default.
• W2754304920 cites W2134539328 @default.
• W2754304920 cites W2136879321 @default.
• W2754304920 cites W2137853125 @default.
• W2754304920 cites W2141630969 @default.
• W2754304920 cites W2147343434 @default.
• W2754304920 cites W2149441684 @default.
• W2754304920 cites W2158465395 @default.
• W2754304920 cites W2162765338 @default.
• W2754304920 cites W2163107106 @default.
• W2754304920 cites W2307262111 @default.
• W2754304920 cites W2375577403 @default.
• W2754304920 cites W2469231232 @default.
• W2754304920 doi "https://doi.org/10.18632/oncotarget.20937" @default.
• W2754304920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5669940" @default.
• W2754304920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29137314" @default.
• W2754304920 hasPublicationYear "2017" @default.
• W2754304920 type Work @default.
• W2754304920 sameAs 2754304920 @default.
• W2754304920 citedByCount "7" @default.
• W2754304920 countsByYear W27543049202019 @default.
• W2754304920 countsByYear W27543049202021 @default.
• W2754304920 countsByYear W27543049202022 @default.
• W2754304920 crossrefType "journal-article" @default.
• W2754304920 hasAuthorship W2754304920A5012515136 @default.
• W2754304920 hasAuthorship W2754304920A5014605070 @default.
• W2754304920 hasAuthorship W2754304920A5019900739 @default.
• W2754304920 hasAuthorship W2754304920A5040393015 @default.
• W2754304920 hasAuthorship W2754304920A5040856605 @default.
• W2754304920 hasAuthorship W2754304920A5041491639 @default.
• W2754304920 hasBestOaLocation W27543049201 @default.
• W2754304920 hasConcept C121608353 @default.
• W2754304920 hasConcept C126322002 @default.
• W2754304920 hasConcept C143998085 @default.
• W2754304920 hasConcept C154456304 @default.
• W2754304920 hasConcept C2777472916 @default.
• W2754304920 hasConcept C2780192828 @default.
• W2754304920 hasConcept C2781278892 @default.
• W2754304920 hasConcept C502942594 @default.
• W2754304920 hasConcept C530470458 @default.
• W2754304920 hasConcept C61367390 @default.
• W2754304920 hasConcept C71924100 @default.
• W2754304920 hasConcept C84606932 @default.
• W2754304920 hasConcept C98717036 @default.
• W2754304920 hasConceptScore W2754304920C121608353 @default.
• W2754304920 hasConceptScore W2754304920C126322002 @default.
• W2754304920 hasConceptScore W2754304920C143998085 @default.
• W2754304920 hasConceptScore W2754304920C154456304 @default.
• W2754304920 hasConceptScore W2754304920C2777472916 @default.
• W2754304920 hasConceptScore W2754304920C2780192828 @default.
• W2754304920 hasConceptScore W2754304920C2781278892 @default.
• W2754304920 hasConceptScore W2754304920C502942594 @default.
• W2754304920 hasConceptScore W2754304920C530470458 @default.
• W2754304920 hasConceptScore W2754304920C61367390 @default.
• W2754304920 hasConceptScore W2754304920C71924100 @default.
• W2754304920 hasConceptScore W2754304920C84606932 @default.
• W2754304920 hasConceptScore W2754304920C98717036 @default.
• W2754304920 hasIssue "47" @default.
• W2754304920 hasLocation W27543049201 @default.
• W2754304920 hasLocation W27543049202 @default.
• W2754304920 hasLocation W27543049203 @default.
• W2754304920 hasLocation W27543049204 @default.
• W2754304920 hasLocation W27543049205 @default.

• next