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• W2756557757 endingPage "17.2017" @default.
• W2756557757 startingPage "ENEURO.0287" @default.
• W2756557757 abstract "Recent studies revealed changes in odor representations in the olfactory bulb during active olfactory learning (Chu et al., 2016; Yamada et al., 2017). Specifically, mitral cell ensemble responses to very similar odorant mixtures sparsened and became more distinguishable as mice learned to discriminate the odorants over days (Chu et al., 2016). In this study, we explored whether changes in the sensory inputs to the bulb underlie the observed changes in mitral cell responses. Using two-photon calcium imaging to monitor the odor responses of the olfactory sensory neuron (OSN) axon terminals in the glomeruli of the olfactory bulb during a discrimination task, we found that OSN inputs to the bulb are stable during discrimination learning. During one week of training to discriminate between very similar odorant mixtures in a Go/No-go task, OSN responses did not show significant sparsening, and the responses to the trained similar odorants did not diverge throughout training. These results suggest that the adaptive changes of mitral cell responses during perceptual learning are ensured by mechanisms downstream of OSN input, possibly in local circuits within olfactory bulb." @default.
• W2756557757 created "2017-10-06" @default.
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• W2756557757 date "2017-09-01" @default.
• W2756557757 modified "2023-10-15" @default.
• W2756557757 title "Lack of Pattern Separation in Sensory Inputs to the Olfactory Bulb during Perceptual Learning" @default.
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• W2756557757 doi "https://doi.org/10.1523/eneuro.0287-17.2017" @default.
• W2756557757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5615249" @default.
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