FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2760758051> ?p ?o ?g. }

• W2760758051 endingPage "e0184875" @default.
• W2760758051 startingPage "e0184875" @default.
• W2760758051 abstract "Objective Scientific research is constantly striving to find molecules which are effective against excessive body fat and its associated complications. Taking into account the beneficial effects that resveratrol exerts on other pathologies through miRNA, the aim of the present work was to analyze the possible involvement of miRNAs in the regulation of adipogenic transcription factors peroxisome proliferator-activated receptor γ (pparγ), CCAAT enhancer-binding proteins α and β (cebpβ and cebpα) induced by resveratrol and its metabolites. Methods 3T3-L1 maturing pre-adipocytes were treated during differentiation with 25 μM of trans-resveratrol (RSV), trans-resveratrol-3-O-sulfate (3S), trans-resveratrol-3'-O-glucuronide (3G) and trans-resveratrol-4'-O-glucuronide (4G). After computational prediction and bibliographic search of miRNAs targeting pparγ, cebpβ and cebpα, the expression of microRNA-130b-3p (miR-130b-3p), microRNA-155-5p (miR-155-5p), microRNA-27b-3p (miR-27b-3p), microRNA-31-5p (miR-31-5p), microRNA-326-3p (miR-326-3p), microRNA-27a-3p (miR-27a-3p), microRNA-144-3p (miR-144-3p), microRNA-205-5p (miR-205-5p) and microRNA-224-3p (miR-224-3p) was analyzed. Moreover, other adipogenic mediators such as sterol regulatory element binding transcription factor 1 (srebf1), krüppel-like factor 5 (klf5), liver x receptor α (lxrα) and cAMP responding element binding protein 1 (creb1), were measured by Real Time RT-PCR. As a confirmatory assay, cells treated with RSV were transfected with anti-miR-155 in order to measure cebpβ gene and protein expressions. Results Of the miRNAs analyzed only miR-155 was modified after resveratrol and glucuronide metabolite treatment. In transfected cells with anti-miR-155, RSV did not reduce cebpβ gene and protein expression. 3S decreased gene expression of creb1, klf5, srebf1 and lxrα. Conclusions While RSV and glucuronide metabolites exert their inhibitory effect on adipogenesis through miR-155 up-regulation, the anti-adipogenic effect of 3S is not mediated via miRNAs." @default.
• W2760758051 created "2017-10-06" @default.
• W2760758051 creator A5011124617 @default.
• W2760758051 creator A5050373974 @default.
• W2760758051 creator A5062420859 @default.
• W2760758051 creator A5077732134 @default.
• W2760758051 creator A5080052018 @default.
• W2760758051 date "2017-09-27" @default.
• W2760758051 modified "2023-10-16" @default.
• W2760758051 title "Potential miRNA involvement in the anti-adipogenic effect of resveratrol and its metabolites" @default.
• W2760758051 cites W144423133 @default.
• W2760758051 cites W1508463584 @default.
• W2760758051 cites W1508727117 @default.
• W2760758051 cites W1558648695 @default.
• W2760758051 cites W1570653911 @default.
• W2760758051 cites W1730059564 @default.
• W2760758051 cites W1848209720 @default.
• W2760758051 cites W1965084904 @default.
• W2760758051 cites W1966927325 @default.
• W2760758051 cites W1970685293 @default.
• W2760758051 cites W1975072242 @default.
• W2760758051 cites W1975120418 @default.
• W2760758051 cites W1981670717 @default.
• W2760758051 cites W1983251404 @default.
• W2760758051 cites W1983979341 @default.
• W2760758051 cites W1987724465 @default.
• W2760758051 cites W1996154370 @default.
• W2760758051 cites W1997490378 @default.
• W2760758051 cites W2001290163 @default.
• W2760758051 cites W2002995168 @default.
• W2760758051 cites W2009188559 @default.
• W2760758051 cites W2011336591 @default.
• W2760758051 cites W2013498640 @default.
• W2760758051 cites W2014018523 @default.
• W2760758051 cites W2014946489 @default.
• W2760758051 cites W2017333606 @default.
• W2760758051 cites W2018174717 @default.
• W2760758051 cites W2025726874 @default.
• W2760758051 cites W2026217498 @default.
• W2760758051 cites W2027943537 @default.
• W2760758051 cites W2035820929 @default.
• W2760758051 cites W2036228374 @default.
• W2760758051 cites W2037977348 @default.
• W2760758051 cites W2041069797 @default.
• W2760758051 cites W2042685638 @default.
• W2760758051 cites W2047461181 @default.
• W2760758051 cites W2052609811 @default.
• W2760758051 cites W2054003772 @default.
• W2760758051 cites W2059992589 @default.
• W2760758051 cites W2061236999 @default.
• W2760758051 cites W2065703867 @default.
• W2760758051 cites W2074619781 @default.
• W2760758051 cites W2077114801 @default.
• W2760758051 cites W2080909665 @default.
• W2760758051 cites W2083471594 @default.
• W2760758051 cites W2084781111 @default.
• W2760758051 cites W2088579093 @default.
• W2760758051 cites W2090029015 @default.
• W2760758051 cites W2091640850 @default.
• W2760758051 cites W2094722560 @default.
• W2760758051 cites W2096003689 @default.
• W2760758051 cites W2098285533 @default.
• W2760758051 cites W2100448400 @default.
• W2760758051 cites W2101284986 @default.
• W2760758051 cites W2107277218 @default.
• W2760758051 cites W2109102102 @default.
• W2760758051 cites W2111439660 @default.
• W2760758051 cites W2124358366 @default.
• W2760758051 cites W2124756133 @default.
• W2760758051 cites W2134511980 @default.
• W2760758051 cites W2135871391 @default.
• W2760758051 cites W2136830554 @default.
• W2760758051 cites W2145058454 @default.
• W2760758051 cites W2161864879 @default.
• W2760758051 cites W2164564178 @default.
• W2760758051 cites W2166243815 @default.
• W2760758051 cites W2170005346 @default.
• W2760758051 cites W2179718752 @default.
• W2760758051 cites W2192080449 @default.
• W2760758051 cites W2295116605 @default.
• W2760758051 cites W2313585100 @default.
• W2760758051 cites W2542315333 @default.
• W2760758051 cites W2554912414 @default.
• W2760758051 cites W2560697578 @default.
• W2760758051 cites W2567373541 @default.
• W2760758051 cites W2579771006 @default.
• W2760758051 cites W2597632520 @default.
• W2760758051 cites W2607227421 @default.
• W2760758051 cites W273240523 @default.
• W2760758051 doi "https://doi.org/10.1371/journal.pone.0184875" @default.
• W2760758051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5617156" @default.
• W2760758051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28953910" @default.
• W2760758051 hasPublicationYear "2017" @default.
• W2760758051 type Work @default.
• W2760758051 sameAs 2760758051 @default.
• W2760758051 citedByCount "36" @default.
• W2760758051 countsByYear W27607580512018 @default.
• W2760758051 countsByYear W27607580512019 @default.

• next