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• W2764175503 abstract "Background: Mountain ginseng (Panax ginseng Meyer), which belongs to Araliaceae family, grows naturally in the&#x0D; mountains of Korea. It is highly valued owing to its enhanced pharmacology effects such as immunostimulating,&#x0D; antioxidant, anti-cancer and antiaging activity. An alternative to accessing the sparse mountain ginseng therapy benefits is&#x0D; by tissue-cultured roots of mountain ginseng. The aim of this study is to evaluate the effect of water extract of cultured&#x0D; roots of mountain ginseng (CRMG) and specifically its major compound ginsenoside Re (Re) on melanin synthesis in α-&#x0D; MSH-stimulated mouse melanoma B16BL6 cells (B16).&#x0D; Materials and Methods: Cell cytotoxicity was evaluated trough a comparative study using normal human dermal&#x0D; fibroblast (HDF) and B16. Then, α-MSH-stimulated B16 cells were analyzed, using melanin and tyrosinase activity assay.&#x0D; Tyrosinase gene expression was evaluated trough reverse transcription polymerase chain reaction analysis and quantitative&#x0D; PCR analysis. Finally, an in silico docking study was performed.&#x0D; Results: The study demonstrated that CRMG and Re were non-toxic compounds and significantly reduced tyrosinase&#x0D; activity and melanin content in B16 cells. Re decreased the mRNA expression of tyrosinase and other melanin synthesisrelated&#x0D; genes in B16 cells. In addition, in silico docking studies showed that Re had stronger interaction with tyrosinase&#x0D; compared to control drug arbutin due to its higher binding affinity.&#x0D; Conclusion: Taken together, our results suggest that CRMG and Re possess potential anti-melanogenic activities and may&#x0D; be used as antimelanogenic cosmeceutical agents." @default.
• W2764175503 created "2017-10-20" @default.
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• W2764175503 date "2017-10-01" @default.
• W2764175503 modified "2023-09-27" @default.
• W2764175503 title "NOVEL APPLICATION OF CULTURED ROOTS OF MOUNTAIN GINSENG (PANAX GINSENG MEYER) AND GINSENOSIDE RE AS SAFE ANTIMELANOGENIC COSMECEUTICAL COMPONENTS" @default.
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• W2764175503 doi "https://doi.org/10.21010/ajtcam.v14i5.24" @default.
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