FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766643399> ?p ?o ?g. }

• W2766643399 endingPage "1994" @default.
• W2766643399 startingPage "1983" @default.
• W2766643399 abstract "Aim: Resistance to conventional antibiotics has spurred interest in exploring new antimicrobial strategies. Suppressing quorum sensing within biofilm is a promising antimicrobial strategy. LasR in quorum sensing system of the Gram-negative bacteria, Pseudomonas aeruginosa, directly enhances virulence and antibiotic resistance, with QscR as its indirect suppressor, so targeting both of them can synergistically take the effect. Methodology/results: An in silico protocol combining pharmacophores with molecular docking was applied. Pharmacophores of QscR agonists and LasR antagonists were prepared for preliminary screening, followed by counter-screen using a pharmacophore model of LasR agonists and molecular docking of LasR. Four compounds with novel scaffolds were confirmed as potential biofilm inhibitors with preliminary experimental data. Conclusion: Novel biofilm inhibitors can be found with the method." @default.
• W2766643399 created "2017-11-10" @default.
• W2766643399 creator A5002241866 @default.
• W2766643399 creator A5005770039 @default.
• W2766643399 creator A5041700307 @default.
• W2766643399 creator A5064726109 @default.
• W2766643399 creator A5077419007 @default.
• W2766643399 date "2017-11-01" @default.
• W2766643399 modified "2023-09-24" @default.
• W2766643399 title "Virtual screening and biological evaluation of biofilm inhibitors on dual targets in quorum sensing system" @default.
• W2766643399 cites W1983200428 @default.
• W2766643399 cites W1997128173 @default.
• W2766643399 cites W2002589169 @default.
• W2766643399 cites W2007002493 @default.
• W2766643399 cites W2014467756 @default.
• W2766643399 cites W2018989138 @default.
• W2766643399 cites W2043960936 @default.
• W2766643399 cites W2048521230 @default.
• W2766643399 cites W2048843475 @default.
• W2766643399 cites W2071483471 @default.
• W2766643399 cites W2079598611 @default.
• W2766643399 cites W2084978938 @default.
• W2766643399 cites W2091680206 @default.
• W2766643399 cites W2127944104 @default.
• W2766643399 cites W2129085142 @default.
• W2766643399 cites W2136847512 @default.
• W2766643399 cites W2140405224 @default.
• W2766643399 cites W2146292204 @default.
• W2766643399 cites W2150051887 @default.
• W2766643399 cites W2156333188 @default.
• W2766643399 cites W2162160645 @default.
• W2766643399 cites W2511941815 @default.
• W2766643399 doi "https://doi.org/10.4155/fmc-2017-0127" @default.
• W2766643399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29076756" @default.
• W2766643399 hasPublicationYear "2017" @default.
• W2766643399 type Work @default.
• W2766643399 sameAs 2766643399 @default.
• W2766643399 citedByCount "12" @default.
• W2766643399 countsByYear W27666433992019 @default.
• W2766643399 countsByYear W27666433992020 @default.
• W2766643399 countsByYear W27666433992021 @default.
• W2766643399 countsByYear W27666433992022 @default.
• W2766643399 crossrefType "journal-article" @default.
• W2766643399 hasAuthorship W2766643399A5002241866 @default.
• W2766643399 hasAuthorship W2766643399A5005770039 @default.
• W2766643399 hasAuthorship W2766643399A5041700307 @default.
• W2766643399 hasAuthorship W2766643399A5064726109 @default.
• W2766643399 hasAuthorship W2766643399A5077419007 @default.
• W2766643399 hasConcept C103697762 @default.
• W2766643399 hasConcept C104317684 @default.
• W2766643399 hasConcept C118687296 @default.
• W2766643399 hasConcept C159110408 @default.
• W2766643399 hasConcept C185592680 @default.
• W2766643399 hasConcept C2775905019 @default.
• W2766643399 hasConcept C2777637488 @default.
• W2766643399 hasConcept C41685203 @default.
• W2766643399 hasConcept C4937899 @default.
• W2766643399 hasConcept C501593827 @default.
• W2766643399 hasConcept C523546767 @default.
• W2766643399 hasConcept C54355233 @default.
• W2766643399 hasConcept C55493867 @default.
• W2766643399 hasConcept C56173144 @default.
• W2766643399 hasConcept C58123911 @default.
• W2766643399 hasConcept C60987743 @default.
• W2766643399 hasConcept C70721500 @default.
• W2766643399 hasConcept C71924100 @default.
• W2766643399 hasConcept C86803240 @default.
• W2766643399 hasConcept C89423630 @default.
• W2766643399 hasConcept C94665300 @default.
• W2766643399 hasConceptScore W2766643399C103697762 @default.
• W2766643399 hasConceptScore W2766643399C104317684 @default.
• W2766643399 hasConceptScore W2766643399C118687296 @default.
• W2766643399 hasConceptScore W2766643399C159110408 @default.
• W2766643399 hasConceptScore W2766643399C185592680 @default.
• W2766643399 hasConceptScore W2766643399C2775905019 @default.
• W2766643399 hasConceptScore W2766643399C2777637488 @default.
• W2766643399 hasConceptScore W2766643399C41685203 @default.
• W2766643399 hasConceptScore W2766643399C4937899 @default.
• W2766643399 hasConceptScore W2766643399C501593827 @default.
• W2766643399 hasConceptScore W2766643399C523546767 @default.
• W2766643399 hasConceptScore W2766643399C54355233 @default.
• W2766643399 hasConceptScore W2766643399C55493867 @default.
• W2766643399 hasConceptScore W2766643399C56173144 @default.
• W2766643399 hasConceptScore W2766643399C58123911 @default.
• W2766643399 hasConceptScore W2766643399C60987743 @default.
• W2766643399 hasConceptScore W2766643399C70721500 @default.
• W2766643399 hasConceptScore W2766643399C71924100 @default.
• W2766643399 hasConceptScore W2766643399C86803240 @default.
• W2766643399 hasConceptScore W2766643399C89423630 @default.
• W2766643399 hasConceptScore W2766643399C94665300 @default.
• W2766643399 hasIssue "17" @default.
• W2766643399 hasLocation W27666433991 @default.
• W2766643399 hasLocation W27666433992 @default.
• W2766643399 hasOpenAccess W2766643399 @default.
• W2766643399 hasPrimaryLocation W27666433991 @default.
• W2766643399 hasRelatedWork W2011599312 @default.
• W2766643399 hasRelatedWork W2052893160 @default.
• W2766643399 hasRelatedWork W2129197708 @default.

• next