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• W2766849641 abstract "Although the frontolimbic cortex has been implicated in borderline personality disorder (BPD), information about possible asymmetries in this region in patients with BPD is limited. This study aimed to examine whether frontolimbic cortex asymmetries differ between patients with BPD and healthy individuals.The brains of 30 young adult patients with BPD and 32 healthy control subjects were scanned with magnetic resonance imaging (MRI). The participants completed self-report scales assessing impulsivity, affect intensity and other psychological variables. Gray matter volume, surface area, and cortical thickness in regions of interest (ROIs), namely anterior insula (AI) and anterior cingulate cortex (ACC) were determined and the data were probed for hemisphere-group interactions.Relative to controls, patients with BPD had reduced cortical thickness in left ACC and less surface area and gray matter volume in left AI. Significant group-hemisphere interactions were observed for gray matter volume and surface area of AI and for cortical thickness of ACC. Post hoc analysis showed that the BPD patients had greater frontolimbic cortex asymmetry than healthy controls; furthermore, greater asymmetry of AI&ACC correlated with a higher score in attention subscale of Barratt Impulsiveness Scale.Patients with BPD have greater frontolimbic asymmetry than healthy individuals." @default.
• W2766849641 created "2017-11-10" @default.
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• W2766849641 date "2017-10-16" @default.
• W2766849641 modified "2023-10-14" @default.
• W2766849641 title "Hemispheric asymmetry of the frontolimbic cortex in young adults with borderline personality disorder" @default.
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• W2766849641 doi "https://doi.org/10.1111/acps.12823" @default.
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