FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767959713> ?p ?o ?g. }

• W2767959713 abstract "Homeostatic regulation of visceral organ function requires integrated processing of neural and neurohormonal sensory signals. The nucleus of the solitary tract (NTS) is the primary sensory nucleus for cranial visceral sensory afferents. Angiotensin II (ANG II) is known to modulate peripheral visceral reflexes, in part, by activating ANG II type 1A receptors (AT 1A R) in the NTS. AT 1A R-expressing NTS neurons occur throughout the NTS with a defined subnuclear distribution, and most of these neurons are depolarized by ANG II. In this study we determined whether AT 1A R-expressing NTS neurons receive direct visceral sensory input, and whether this input is modulated by ANG II. Using AT 1A R-GFP mice to make targeted whole cell recordings from AT 1A R-expressing NTS neurons, we demonstrate that two-thirds (37 of 56) of AT 1A R-expressing neurons receive direct excitatory, visceral sensory input. In half of the neurons tested (4 of 8) the excitatory visceral sensory input was significantly reduced by application of the transient receptor potential vallinoid type 1 receptor agonist, capsaicin, indicating AT 1A R-expressing neurons can receive either C- or A-fiber-mediated input. Application of ANG II to a subset of second-order AT 1A R-expressing neurons did not affect spontaneous, evoked, or asynchronous glutamate release from visceral sensory afferents. Thus it is unlikely that AT 1A R-expressing viscerosensory neurons terminate on AT 1A R-expressing NTS neurons. Our data suggest that ANG II is likely to modulate multiple visceral sensory modalities by altering the excitability of second-order AT 1A R-expressing NTS neurons." @default.
• W2767959713 created "2017-11-17" @default.
• W2767959713 creator A5014979834 @default.
• W2767959713 creator A5015461261 @default.
• W2767959713 creator A5015532467 @default.
• W2767959713 creator A5018735152 @default.
• W2767959713 creator A5056800292 @default.
• W2767959713 creator A5080527799 @default.
• W2767959713 creator A5090789244 @default.
• W2767959713 date "2018-02-01" @default.
• W2767959713 modified "2023-10-17" @default.
• W2767959713 title "Viscerosensory input drives angiotensin II type 1A receptor-expressing neurons in the solitary tract nucleus" @default.
• W2767959713 cites W1508717283 @default.
• W2767959713 cites W1509240027 @default.
• W2767959713 cites W1855031790 @default.
• W2767959713 cites W1966421966 @default.
• W2767959713 cites W1969127339 @default.
• W2767959713 cites W1969934675 @default.
• W2767959713 cites W1973416055 @default.
• W2767959713 cites W1978917621 @default.
• W2767959713 cites W1980010331 @default.
• W2767959713 cites W1980277574 @default.
• W2767959713 cites W1984163963 @default.
• W2767959713 cites W1991517583 @default.
• W2767959713 cites W2003490751 @default.
• W2767959713 cites W2008048120 @default.
• W2767959713 cites W2015470362 @default.
• W2767959713 cites W2017861035 @default.
• W2767959713 cites W2019646726 @default.
• W2767959713 cites W2028281748 @default.
• W2767959713 cites W2035404960 @default.
• W2767959713 cites W2041193789 @default.
• W2767959713 cites W2041971204 @default.
• W2767959713 cites W2045032238 @default.
• W2767959713 cites W2046587771 @default.
• W2767959713 cites W2048870600 @default.
• W2767959713 cites W2056186896 @default.
• W2767959713 cites W2056335561 @default.
• W2767959713 cites W2058878434 @default.
• W2767959713 cites W2059067935 @default.
• W2767959713 cites W2059299783 @default.
• W2767959713 cites W2062806009 @default.
• W2767959713 cites W2063615964 @default.
• W2767959713 cites W2063833874 @default.
• W2767959713 cites W2067333980 @default.
• W2767959713 cites W2074804857 @default.
• W2767959713 cites W2079226885 @default.
• W2767959713 cites W2082853303 @default.
• W2767959713 cites W2083137154 @default.
• W2767959713 cites W2092563709 @default.
• W2767959713 cites W2100528030 @default.
• W2767959713 cites W2119445933 @default.
• W2767959713 cites W2122525016 @default.
• W2767959713 cites W2124418433 @default.
• W2767959713 cites W2130666985 @default.
• W2767959713 cites W2138661882 @default.
• W2767959713 cites W2142090985 @default.
• W2767959713 cites W2145475206 @default.
• W2767959713 cites W2151577814 @default.
• W2767959713 cites W2161075936 @default.
• W2767959713 cites W2162341082 @default.
• W2767959713 cites W2168767331 @default.
• W2767959713 cites W2186426742 @default.
• W2767959713 cites W2199915640 @default.
• W2767959713 cites W2258112243 @default.
• W2767959713 cites W2293003331 @default.
• W2767959713 cites W2313451336 @default.
• W2767959713 cites W2340082412 @default.
• W2767959713 cites W2511599610 @default.
• W2767959713 cites W2519579226 @default.
• W2767959713 cites W2591094931 @default.
• W2767959713 cites W2600858003 @default.
• W2767959713 cites W2735465273 @default.
• W2767959713 doi "https://doi.org/10.1152/ajpregu.00290.2017" @default.
• W2767959713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29118020" @default.
• W2767959713 hasPublicationYear "2018" @default.
• W2767959713 type Work @default.
• W2767959713 sameAs 2767959713 @default.
• W2767959713 citedByCount "1" @default.
• W2767959713 countsByYear W27679597132019 @default.
• W2767959713 crossrefType "journal-article" @default.
• W2767959713 hasAuthorship W2767959713A5014979834 @default.
• W2767959713 hasAuthorship W2767959713A5015461261 @default.
• W2767959713 hasAuthorship W2767959713A5015532467 @default.
• W2767959713 hasAuthorship W2767959713A5018735152 @default.
• W2767959713 hasAuthorship W2767959713A5056800292 @default.
• W2767959713 hasAuthorship W2767959713A5080527799 @default.
• W2767959713 hasAuthorship W2767959713A5090789244 @default.
• W2767959713 hasBestOaLocation W27679597131 @default.
• W2767959713 hasConcept C112592302 @default.
• W2767959713 hasConcept C169760540 @default.
• W2767959713 hasConcept C170493617 @default.
• W2767959713 hasConcept C17077164 @default.
• W2767959713 hasConcept C2779929655 @default.
• W2767959713 hasConcept C2780723820 @default.
• W2767959713 hasConcept C2780838160 @default.
• W2767959713 hasConcept C2908929049 @default.
• W2767959713 hasConcept C55493867 @default.
• W2767959713 hasConcept C61174792 @default.
• W2767959713 hasConcept C86803240 @default.

• next