FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769055144> ?p ?o ?g. }

• W2769055144 abstract "Cells of the myeloid lineage, particularly macrophages, serve as primary hosts for HIV in vivo, along with CD4 T lymphocytes. Macrophages are present in virtually every tissue of the organism, including locations with negligible T cell colonization, such as the brain, where HIV-mediated inflammation may lead to pathological sequelae. Moreover, infected macrophages are present in multiple other tissues. Recent evidence obtained in humanized mice and macaque models highlighted the capacity of macrophages to sustain HIV replication in vivo in the absence of T cells. Combined with the known resistance of the macrophage to the cytopathic effects of HIV infection, such data brings a renewed interest in this cell type both as a vehicle for viral spread as well as a viral reservoir. While our understanding of key processes of HIV infection of macrophages is far from complete, recent years have nevertheless brought important insight into the uniqueness of the macrophage infection. Productive infection of macrophages by HIV can occur by different routes including from phagocytosis of infected T cells. In macrophages, HIV assembles and buds into a peculiar plasma-membrane-connected compartment that pre-exists to the infection. While the function of such compartment remains elusive, it supposedly allows for the persistence of infectious viral particles over extended periods of time and may play a role on viral transmission. As cells of the innate immune system, macrophages have the capacity to detect and respond to viral components. Recent data suggest that such sensing may occur at multiple steps of the viral cycle and impact subsequent viral spread. We aim to provide an overview of the HIV-macrophage interaction along the multiple stages of the viral life cycle, extending when pertinent such observations to additional myeloid cell types such as dendritic cells or blood monocytes." @default.
• W2769055144 created "2017-12-04" @default.
• W2769055144 creator A5017635626 @default.
• W2769055144 creator A5062968725 @default.
• W2769055144 creator A5080468934 @default.
• W2769055144 creator A5084495245 @default.
• W2769055144 date "2017-11-30" @default.
• W2769055144 modified "2023-09-26" @default.
• W2769055144 title "Myeloid Cell Interaction with HIV: A Complex Relationship" @default.
• W2769055144 cites W1481565722 @default.
• W2769055144 cites W1485557578 @default.
• W2769055144 cites W1512110864 @default.
• W2769055144 cites W1530953794 @default.
• W2769055144 cites W1549854676 @default.
• W2769055144 cites W1565428981 @default.
• W2769055144 cites W1570518269 @default.
• W2769055144 cites W1601323025 @default.
• W2769055144 cites W1602227127 @default.
• W2769055144 cites W1674676016 @default.
• W2769055144 cites W1793297159 @default.
• W2769055144 cites W1840537526 @default.
• W2769055144 cites W1857710144 @default.
• W2769055144 cites W188740783 @default.
• W2769055144 cites W1931451499 @default.
• W2769055144 cites W1964567249 @default.
• W2769055144 cites W1965818140 @default.
• W2769055144 cites W1972049853 @default.
• W2769055144 cites W1973433801 @default.
• W2769055144 cites W1977536320 @default.
• W2769055144 cites W1980923315 @default.
• W2769055144 cites W1980926787 @default.
• W2769055144 cites W1981513494 @default.
• W2769055144 cites W1982335810 @default.
• W2769055144 cites W1983262897 @default.
• W2769055144 cites W1984999783 @default.
• W2769055144 cites W1985859986 @default.
• W2769055144 cites W1989767992 @default.
• W2769055144 cites W1990773400 @default.
• W2769055144 cites W1991586131 @default.
• W2769055144 cites W1992007798 @default.
• W2769055144 cites W1995045410 @default.
• W2769055144 cites W1998016101 @default.
• W2769055144 cites W1999396723 @default.
• W2769055144 cites W2004345778 @default.
• W2769055144 cites W2006737262 @default.
• W2769055144 cites W2008998239 @default.
• W2769055144 cites W2010072143 @default.
• W2769055144 cites W2010458160 @default.
• W2769055144 cites W2011208161 @default.
• W2769055144 cites W2012784876 @default.
• W2769055144 cites W2021500400 @default.
• W2769055144 cites W2022450093 @default.
• W2769055144 cites W2023635183 @default.
• W2769055144 cites W2023650881 @default.
• W2769055144 cites W2026616659 @default.
• W2769055144 cites W2026927504 @default.
• W2769055144 cites W2028131627 @default.
• W2769055144 cites W2028170369 @default.
• W2769055144 cites W2030391162 @default.
• W2769055144 cites W2032185832 @default.
• W2769055144 cites W2034996626 @default.
• W2769055144 cites W2035581654 @default.
• W2769055144 cites W2036235452 @default.
• W2769055144 cites W2036932383 @default.
• W2769055144 cites W2038350488 @default.
• W2769055144 cites W2041774032 @default.
• W2769055144 cites W2042982138 @default.
• W2769055144 cites W2044273929 @default.
• W2769055144 cites W2044393507 @default.
• W2769055144 cites W2044873867 @default.
• W2769055144 cites W2044986106 @default.
• W2769055144 cites W2046159404 @default.
• W2769055144 cites W2047452261 @default.
• W2769055144 cites W2050070282 @default.
• W2769055144 cites W2053445583 @default.
• W2769055144 cites W2053584325 @default.
• W2769055144 cites W2056849508 @default.
• W2769055144 cites W2058507546 @default.
• W2769055144 cites W2064140898 @default.
• W2769055144 cites W2064524099 @default.
• W2769055144 cites W2066106215 @default.
• W2769055144 cites W2066121768 @default.
• W2769055144 cites W2069554621 @default.
• W2769055144 cites W2070307339 @default.
• W2769055144 cites W2072462631 @default.
• W2769055144 cites W2074582729 @default.
• W2769055144 cites W2077057101 @default.
• W2769055144 cites W2077620427 @default.
• W2769055144 cites W2077798597 @default.
• W2769055144 cites W2077915242 @default.
• W2769055144 cites W2079238181 @default.
• W2769055144 cites W2081550246 @default.
• W2769055144 cites W2081969699 @default.
• W2769055144 cites W2084803259 @default.
• W2769055144 cites W2086137483 @default.
• W2769055144 cites W2090123041 @default.
• W2769055144 cites W2090646713 @default.
• W2769055144 cites W2091140326 @default.
• W2769055144 cites W2092524383 @default.
• W2769055144 cites W2096621401 @default.

• next