FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772023181> ?p ?o ?g. }

• W2772023181 abstract "The need for novel biomarkers that could aid in non-small cell lung cancer (NSCLC) detection, together with the relevance of Matrix Metalloproteases (MMPs) -1, -2, -7, -9 and -10 in lung tumorigenesis, prompted us to assess the diagnostic usefulness of these MMPs and the Tissue Inhibitor of Metalloproteinase (TIMP) -1 in NSCLC patients.Markers were evaluated in an initial study cohort (19 NSCLC cases and 19 healthy controls). Those that better performed were analyzed in a larger sample including patients with benign lung diseases. Serum MMPs and TIMP-1 were determined by multiplexed immunoassays. Logistic regression was employed for multivariate analysis of biomarker combinations.MMPs and TIMP-1 were elevated in the serum of NSCLC patients compared to healthy controls. MMP-1, -7 and -9 performed at best and were further evaluated in the sample including benign pathologies, corroborating the superiority of MMP-9 in NSCLC discrimination, also at early-stage NSCLC. The optimal diagnostic value was obtained with the model including MMP-9, gender, age and smoking history, that demonstrated an AUC of 0.787, 85.54% sensitivity and 64.89% specificity.Our results suggest that MMP-9 is a potential biomarker for NSCLC diagnosis and its combined measurement with other biomarkers could improve NSCLC detection." @default.
• W2772023181 created "2017-12-22" @default.
• W2772023181 creator A5016315336 @default.
• W2772023181 creator A5047607060 @default.
• W2772023181 creator A5048598640 @default.
• W2772023181 creator A5052238284 @default.
• W2772023181 creator A5054005649 @default.
• W2772023181 creator A5062354912 @default.
• W2772023181 creator A5069263136 @default.
• W2772023181 creator A5083351132 @default.
• W2772023181 date "2017-12-01" @default.
• W2772023181 modified "2023-10-17" @default.
• W2772023181 title "Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis" @default.
• W2772023181 cites W1264489 @default.
• W2772023181 cites W1531310094 @default.
• W2772023181 cites W1823895403 @default.
• W2772023181 cites W1965751894 @default.
• W2772023181 cites W1966114315 @default.
• W2772023181 cites W1985106893 @default.
• W2772023181 cites W1989078440 @default.
• W2772023181 cites W1989376781 @default.
• W2772023181 cites W1992588954 @default.
• W2772023181 cites W1992885568 @default.
• W2772023181 cites W2003500892 @default.
• W2772023181 cites W2005334224 @default.
• W2772023181 cites W2005376824 @default.
• W2772023181 cites W2010715204 @default.
• W2772023181 cites W2046968962 @default.
• W2772023181 cites W2047987355 @default.
• W2772023181 cites W2050834003 @default.
• W2772023181 cites W2062250788 @default.
• W2772023181 cites W2072585533 @default.
• W2772023181 cites W2075026880 @default.
• W2772023181 cites W2081600938 @default.
• W2772023181 cites W2083297935 @default.
• W2772023181 cites W2085386030 @default.
• W2772023181 cites W2100989340 @default.
• W2772023181 cites W2105454075 @default.
• W2772023181 cites W2114619327 @default.
• W2772023181 cites W2118147646 @default.
• W2772023181 cites W2120803202 @default.
• W2772023181 cites W2121317746 @default.
• W2772023181 cites W2141490694 @default.
• W2772023181 cites W2146074984 @default.
• W2772023181 cites W2156717187 @default.
• W2772023181 cites W2159152965 @default.
• W2772023181 cites W2160639837 @default.
• W2772023181 cites W2196694453 @default.
• W2772023181 cites W2341211723 @default.
• W2772023181 cites W3150590867 @default.
• W2772023181 doi "https://doi.org/10.1186/s12885-017-3842-z" @default.
• W2772023181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5718060" @default.
• W2772023181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29207990" @default.
• W2772023181 hasPublicationYear "2017" @default.
• W2772023181 type Work @default.
• W2772023181 sameAs 2772023181 @default.
• W2772023181 citedByCount "32" @default.
• W2772023181 countsByYear W27720231812018 @default.
• W2772023181 countsByYear W27720231812019 @default.
• W2772023181 countsByYear W27720231812020 @default.
• W2772023181 countsByYear W27720231812021 @default.
• W2772023181 countsByYear W27720231812022 @default.
• W2772023181 countsByYear W27720231812023 @default.
• W2772023181 crossrefType "journal-article" @default.
• W2772023181 hasAuthorship W2772023181A5016315336 @default.
• W2772023181 hasAuthorship W2772023181A5047607060 @default.
• W2772023181 hasAuthorship W2772023181A5048598640 @default.
• W2772023181 hasAuthorship W2772023181A5052238284 @default.
• W2772023181 hasAuthorship W2772023181A5054005649 @default.
• W2772023181 hasAuthorship W2772023181A5062354912 @default.
• W2772023181 hasAuthorship W2772023181A5069263136 @default.
• W2772023181 hasAuthorship W2772023181A5083351132 @default.
• W2772023181 hasBestOaLocation W27720231811 @default.
• W2772023181 hasConcept C109523444 @default.
• W2772023181 hasConcept C121608353 @default.
• W2772023181 hasConcept C126322002 @default.
• W2772023181 hasConcept C143998085 @default.
• W2772023181 hasConcept C146357865 @default.
• W2772023181 hasConcept C151730666 @default.
• W2772023181 hasConcept C2776256026 @default.
• W2772023181 hasConcept C2780140570 @default.
• W2772023181 hasConcept C2781197716 @default.
• W2772023181 hasConcept C55493867 @default.
• W2772023181 hasConcept C555283112 @default.
• W2772023181 hasConcept C63363279 @default.
• W2772023181 hasConcept C71924100 @default.
• W2772023181 hasConcept C86803240 @default.
• W2772023181 hasConceptScore W2772023181C109523444 @default.
• W2772023181 hasConceptScore W2772023181C121608353 @default.
• W2772023181 hasConceptScore W2772023181C126322002 @default.
• W2772023181 hasConceptScore W2772023181C143998085 @default.
• W2772023181 hasConceptScore W2772023181C146357865 @default.
• W2772023181 hasConceptScore W2772023181C151730666 @default.
• W2772023181 hasConceptScore W2772023181C2776256026 @default.
• W2772023181 hasConceptScore W2772023181C2780140570 @default.
• W2772023181 hasConceptScore W2772023181C2781197716 @default.
• W2772023181 hasConceptScore W2772023181C55493867 @default.
• W2772023181 hasConceptScore W2772023181C555283112 @default.
• W2772023181 hasConceptScore W2772023181C63363279 @default.
• W2772023181 hasConceptScore W2772023181C71924100 @default.

• next