FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777278045> ?p ?o ?g. }

• W2777278045 endingPage "537" @default.
• W2777278045 startingPage "521" @default.
• W2777278045 abstract "Adenosine-to-inosine (A-to-I) editing is widespread across the kingdom Metazoa. However, for the lack of comprehensive analysis in nonmodel animals, the evolutionary history of A-to-I editing remains largely unexplored. Here, we detect high-confidence editing sites using clustering and conservation strategies based on RNA sequencing data alone, without using single-nucleotide polymorphism information or genome sequencing data from the same sample. We thereby unveil the first evolutionary landscape of A-to-I editing maps across 20 metazoan species (from worm to human), providing unprecedented evidence on how the editing mechanism gradually expands its territory and increases its influence along the history of evolution. Our result revealed that highly clustered and conserved editing sites tended to have a higher editing level and a higher magnitude of the ADAR motif. The ratio of the frequencies of nonsynonymous editing to that of synonymous editing remarkably increased with increasing the conservation level of A-to-I editing. These results thus suggest potentially functional benefit of highly clustered and conserved editing sites. In addition, spatiotemporal dynamics analyses reveal a conserved enrichment of editing and ADAR expression in the central nervous system throughout more than 300 Myr of divergent evolution in complex animals and the comparability of editing patterns between invertebrates and between vertebrates during development. This study provides evolutionary and dynamic aspects of A-to-I editome across metazoan species, expanding this important but understudied class of nongenomically encoded events for comprehensive characterization." @default.
• W2777278045 created "2018-01-05" @default.
• W2777278045 creator A5030069448 @default.
• W2777278045 creator A5031571854 @default.
• W2777278045 creator A5033293797 @default.
• W2777278045 creator A5046481581 @default.
• W2777278045 creator A5047988084 @default.
• W2777278045 creator A5059510263 @default.
• W2777278045 creator A5060614743 @default.
• W2777278045 creator A5063284158 @default.
• W2777278045 date "2017-12-26" @default.
• W2777278045 modified "2023-10-17" @default.
• W2777278045 title "An Evolutionary Landscape of A-to-I RNA Editome across Metazoan Species" @default.
• W2777278045 cites W1547213195 @default.
• W2777278045 cites W1696199194 @default.
• W2777278045 cites W1876187287 @default.
• W2777278045 cites W1938880134 @default.
• W2777278045 cites W1963856309 @default.
• W2777278045 cites W1969219020 @default.
• W2777278045 cites W1970703807 @default.
• W2777278045 cites W1972257514 @default.
• W2777278045 cites W1974450466 @default.
• W2777278045 cites W1977627012 @default.
• W2777278045 cites W1977957409 @default.
• W2777278045 cites W1984224524 @default.
• W2777278045 cites W1985317176 @default.
• W2777278045 cites W1987530472 @default.
• W2777278045 cites W1994901510 @default.
• W2777278045 cites W1997892086 @default.
• W2777278045 cites W2000326737 @default.
• W2777278045 cites W2007495581 @default.
• W2777278045 cites W2007558709 @default.
• W2777278045 cites W2008476211 @default.
• W2777278045 cites W2012800815 @default.
• W2777278045 cites W2022192230 @default.
• W2777278045 cites W2023923807 @default.
• W2777278045 cites W2035653590 @default.
• W2777278045 cites W2040839903 @default.
• W2777278045 cites W2054421148 @default.
• W2777278045 cites W2054584406 @default.
• W2777278045 cites W2060270119 @default.
• W2777278045 cites W2060909469 @default.
• W2777278045 cites W2061680089 @default.
• W2777278045 cites W2062714021 @default.
• W2777278045 cites W2063538505 @default.
• W2777278045 cites W2068553171 @default.
• W2777278045 cites W2070280958 @default.
• W2777278045 cites W2074562954 @default.
• W2777278045 cites W2083122704 @default.
• W2777278045 cites W2086764744 @default.
• W2777278045 cites W2087464200 @default.
• W2777278045 cites W2097496308 @default.
• W2777278045 cites W2100984579 @default.
• W2777278045 cites W2103441770 @default.
• W2777278045 cites W2105241705 @default.
• W2777278045 cites W2108234281 @default.
• W2777278045 cites W2112113834 @default.
• W2777278045 cites W2118327550 @default.
• W2777278045 cites W2118390701 @default.
• W2777278045 cites W2120224547 @default.
• W2777278045 cites W2123497973 @default.
• W2777278045 cites W2125555353 @default.
• W2777278045 cites W2127365846 @default.
• W2777278045 cites W2131548106 @default.
• W2777278045 cites W2132886196 @default.
• W2777278045 cites W2137786443 @default.
• W2777278045 cites W2141855242 @default.
• W2777278045 cites W2143102422 @default.
• W2777278045 cites W2150138226 @default.
• W2777278045 cites W2154431984 @default.
• W2777278045 cites W2156538352 @default.
• W2777278045 cites W2158166257 @default.
• W2777278045 cites W2160799235 @default.
• W2777278045 cites W2167852161 @default.
• W2777278045 cites W2170786603 @default.
• W2777278045 cites W2291924162 @default.
• W2777278045 cites W2400869935 @default.
• W2777278045 cites W2462097907 @default.
• W2777278045 cites W2470212121 @default.
• W2777278045 cites W2504403190 @default.
• W2777278045 cites W2510286488 @default.
• W2777278045 cites W2527456406 @default.
• W2777278045 cites W2604831109 @default.
• W2777278045 cites W2737812443 @default.
• W2777278045 cites W3102334290 @default.
• W2777278045 doi "https://doi.org/10.1093/gbe/evx277" @default.
• W2777278045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5800060" @default.
• W2777278045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29294013" @default.
• W2777278045 hasPublicationYear "2017" @default.
• W2777278045 type Work @default.
• W2777278045 sameAs 2777278045 @default.
• W2777278045 citedByCount "19" @default.
• W2777278045 countsByYear W27772780452018 @default.
• W2777278045 countsByYear W27772780452019 @default.
• W2777278045 countsByYear W27772780452020 @default.
• W2777278045 countsByYear W27772780452022 @default.
• W2777278045 countsByYear W27772780452023 @default.
• W2777278045 crossrefType "journal-article" @default.

• next