FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2781036673> ?p ?o ?g. }

• W2781036673 endingPage "2835" @default.
• W2781036673 startingPage "2829" @default.
• W2781036673 abstract "Background: Safflower extract and aceglutamide (SA) has been used clinically for the treatment of cerebrovascular diseases such as cerebral embolism, hemorrhage, and mental deterioration. This study aimed to investigate the effect and mechanism of SA injection in the recovery of peripheral innervations of diabetic mice. Methods: The C57BL/6 male mice were divided into four groups: normal control group (n = 44), diabetic group (n = 44), diabetic + SA group (diabetic mice treated with SA injection, n = 44), and diabetic + SA + vascular endothelial growth factor receptor (VEGFR)1-BL group (diabetic mice treated with SA injection and VEGFR 1 blocking antibody n = 24). The streptozotocin-induced diabetic mice model and injured peripheral nerve mice model were built. The mice with injured peripheral nerves were intraperitonealy administered with SA injection for successive 21 days. The corneal sensitivity, number of corneal nerve fibers, and contents of vascular endothelial growth factor (VEGF)-B and various neurotrophic factors such as nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) in corneal tissue of four groups were observed. Results: The diabetic group showed decreased number of corneal nerve fibers, compared with the control group (P = 0.002). And compared with the diabetic group, the diabetic + SA group showed a significant increase in the number of nerve fibers (P = 0.024) and the contents of VEGF-B, NGF, and GDNF in the cornea (all P < 0.05). However, when the diabetic mice were treated with the blocking antibodies specialized for VEGF-B receptor, the neutralization of VEGFR-1 completely abolished the increased expression of NGF and GDNF stimulated by SA injection. Conclusions: SA injection could reduce the nerve injury caused by diabetic peripheral neuropathy, and its protective effect might be associated with the promotion of the expressions of VEGF-B, NGF, and GDNF." @default.
• W2781036673 created "2018-01-05" @default.
• W2781036673 creator A5004145725 @default.
• W2781036673 creator A5010758631 @default.
• W2781036673 creator A5042788229 @default.
• W2781036673 creator A5045912055 @default.
• W2781036673 creator A5079738340 @default.
• W2781036673 date "2017-12-05" @default.
• W2781036673 modified "2023-09-22" @default.
• W2781036673 title "Safflower Extract and Aceglutamide Injection Promoting Recovery of Peripheral Innervations via Vascular Endothelial Growth Factor-B Signaling in Diabetic Mice" @default.
• W2781036673 cites W1581360979 @default.
• W2781036673 cites W1896650885 @default.
• W2781036673 cites W1973681213 @default.
• W2781036673 cites W2003514103 @default.
• W2781036673 cites W2006086569 @default.
• W2781036673 cites W2025988857 @default.
• W2781036673 cites W2030360092 @default.
• W2781036673 cites W2041738284 @default.
• W2781036673 cites W2048638072 @default.
• W2781036673 cites W2049270721 @default.
• W2781036673 cites W2053369310 @default.
• W2781036673 cites W2057100530 @default.
• W2781036673 cites W2061701899 @default.
• W2781036673 cites W2083658185 @default.
• W2781036673 cites W2119513113 @default.
• W2781036673 cites W2125192579 @default.
• W2781036673 cites W2140521575 @default.
• W2781036673 cites W2144966500 @default.
• W2781036673 cites W2158147611 @default.
• W2781036673 cites W2168261002 @default.
• W2781036673 cites W2171480372 @default.
• W2781036673 cites W2460530547 @default.
• W2781036673 cites W2520221904 @default.
• W2781036673 cites W2572131448 @default.
• W2781036673 cites W4298853416 @default.
• W2781036673 doi "https://doi.org/10.4103/0366-6999.219143" @default.
• W2781036673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5717862" @default.
• W2781036673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29176141" @default.
• W2781036673 hasPublicationYear "2017" @default.
• W2781036673 type Work @default.
• W2781036673 sameAs 2781036673 @default.
• W2781036673 citedByCount "8" @default.
• W2781036673 countsByYear W27810366732018 @default.
• W2781036673 countsByYear W27810366732019 @default.
• W2781036673 countsByYear W27810366732022 @default.
• W2781036673 countsByYear W27810366732023 @default.
• W2781036673 crossrefType "journal-article" @default.
• W2781036673 hasAuthorship W2781036673A5004145725 @default.
• W2781036673 hasAuthorship W2781036673A5010758631 @default.
• W2781036673 hasAuthorship W2781036673A5042788229 @default.
• W2781036673 hasAuthorship W2781036673A5045912055 @default.
• W2781036673 hasAuthorship W2781036673A5079738340 @default.
• W2781036673 hasBestOaLocation W27810366731 @default.
• W2781036673 hasConcept C126322002 @default.
• W2781036673 hasConcept C134018914 @default.
• W2781036673 hasConcept C160539049 @default.
• W2781036673 hasConcept C167734588 @default.
• W2781036673 hasConcept C170493617 @default.
• W2781036673 hasConcept C185856081 @default.
• W2781036673 hasConcept C2777025900 @default.
• W2781036673 hasConcept C2778423431 @default.
• W2781036673 hasConcept C2779280383 @default.
• W2781036673 hasConcept C46762472 @default.
• W2781036673 hasConcept C555293320 @default.
• W2781036673 hasConcept C71924100 @default.
• W2781036673 hasConceptScore W2781036673C126322002 @default.
• W2781036673 hasConceptScore W2781036673C134018914 @default.
• W2781036673 hasConceptScore W2781036673C160539049 @default.
• W2781036673 hasConceptScore W2781036673C167734588 @default.
• W2781036673 hasConceptScore W2781036673C170493617 @default.
• W2781036673 hasConceptScore W2781036673C185856081 @default.
• W2781036673 hasConceptScore W2781036673C2777025900 @default.
• W2781036673 hasConceptScore W2781036673C2778423431 @default.
• W2781036673 hasConceptScore W2781036673C2779280383 @default.
• W2781036673 hasConceptScore W2781036673C46762472 @default.
• W2781036673 hasConceptScore W2781036673C555293320 @default.
• W2781036673 hasConceptScore W2781036673C71924100 @default.
• W2781036673 hasIssue "23" @default.
• W2781036673 hasLocation W27810366731 @default.
• W2781036673 hasLocation W27810366732 @default.
• W2781036673 hasLocation W27810366733 @default.
• W2781036673 hasLocation W27810366734 @default.
• W2781036673 hasOpenAccess W2781036673 @default.
• W2781036673 hasPrimaryLocation W27810366731 @default.
• W2781036673 hasRelatedWork W1993597219 @default.
• W2781036673 hasRelatedWork W1995071802 @default.
• W2781036673 hasRelatedWork W2011709829 @default.
• W2781036673 hasRelatedWork W2055342276 @default.
• W2781036673 hasRelatedWork W2092993950 @default.
• W2781036673 hasRelatedWork W2095626059 @default.
• W2781036673 hasRelatedWork W2140892006 @default.
• W2781036673 hasRelatedWork W2403276257 @default.
• W2781036673 hasRelatedWork W2781036673 @default.
• W2781036673 hasRelatedWork W2951672096 @default.
• W2781036673 hasVolume "130" @default.
• W2781036673 isParatext "false" @default.
• W2781036673 isRetracted "false" @default.
• W2781036673 magId "2781036673" @default.

• next