FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783180147> ?p ?o ?g. }

• W2783180147 endingPage "78" @default.
• W2783180147 startingPage "63" @default.
• W2783180147 abstract "Following stroke, the damaged tissue undergoes liquefactive necrosis, a stage of infarct resolution that lasts for months although the exact length of time is currently unknown. One method of repair involves reactive astrocytes and microglia forming a glial scar to compartmentalize the area of liquefactive necrosis from the rest of the brain. The formation of the glial scar is a critical component of the healing response to stroke, as well as other central nervous system (CNS) injuries. The goal of this study was to evaluate the toxicity of the extracellular fluid present in areas of liquefactive necrosis and determine how effectively it is segregated from the remainder of the brain. To accomplish this goal, we used a mouse model of stroke in conjunction with an extracellular fluid toxicity assay, fluorescent and electron microscopy, immunostaining, tracer injections into the infarct, and multiplex immunoassays. We confirmed that the extracellular fluid present in areas of liquefactive necrosis following stroke is toxic to primary cortical and hippocampal neurons for at least 7 weeks following stroke, and discovered that although glial scars are robust physical and endocytic barriers, they are nevertheless permeable. We found that molecules present in the area of liquefactive necrosis can leak across the glial scar and are removed by a combination of paravascular clearance and microglial endocytosis in the adjacent tissue. Despite these mechanisms, there is delayed atrophy, cytotoxic edema, and neuron loss in regions adjacent to the infarct for weeks following stroke. These findings suggest that one mechanism of neurodegeneration following stroke is the failure of glial scars to impermeably segregate areas of liquefactive necrosis from surviving brain tissue." @default.
• W2783180147 created "2018-01-26" @default.
• W2783180147 creator A5006434172 @default.
• W2783180147 creator A5018394545 @default.
• W2783180147 creator A5019824956 @default.
• W2783180147 creator A5020054057 @default.
• W2783180147 creator A5024969225 @default.
• W2783180147 creator A5038423476 @default.
• W2783180147 creator A5053847194 @default.
• W2783180147 creator A5069819013 @default.
• W2783180147 creator A5077559930 @default.
• W2783180147 creator A5078093298 @default.
• W2783180147 creator A5079084859 @default.
• W2783180147 creator A5079616106 @default.
• W2783180147 creator A5081363314 @default.
• W2783180147 date "2018-04-01" @default.
• W2783180147 modified "2023-10-14" @default.
• W2783180147 title "Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts" @default.
• W2783180147 cites W1484398243 @default.
• W2783180147 cites W1488124756 @default.
• W2783180147 cites W1652524709 @default.
• W2783180147 cites W1682207880 @default.
• W2783180147 cites W1967587058 @default.
• W2783180147 cites W1967922486 @default.
• W2783180147 cites W1969184610 @default.
• W2783180147 cites W1969619562 @default.
• W2783180147 cites W1987362442 @default.
• W2783180147 cites W1992903980 @default.
• W2783180147 cites W1998080268 @default.
• W2783180147 cites W1999235115 @default.
• W2783180147 cites W2002578188 @default.
• W2783180147 cites W2005675003 @default.
• W2783180147 cites W2013683961 @default.
• W2783180147 cites W2014022174 @default.
• W2783180147 cites W2015541518 @default.
• W2783180147 cites W2023749167 @default.
• W2783180147 cites W2024955728 @default.
• W2783180147 cites W2026257843 @default.
• W2783180147 cites W2027953381 @default.
• W2783180147 cites W2042914526 @default.
• W2783180147 cites W2043052859 @default.
• W2783180147 cites W2049659704 @default.
• W2783180147 cites W2049675290 @default.
• W2783180147 cites W2053383237 @default.
• W2783180147 cites W2056313120 @default.
• W2783180147 cites W2067727468 @default.
• W2783180147 cites W2069845573 @default.
• W2783180147 cites W2073607297 @default.
• W2783180147 cites W2075107763 @default.
• W2783180147 cites W2078412655 @default.
• W2783180147 cites W2079320514 @default.
• W2783180147 cites W2080154692 @default.
• W2783180147 cites W2080518662 @default.
• W2783180147 cites W2084484659 @default.
• W2783180147 cites W2093374391 @default.
• W2783180147 cites W2094115917 @default.
• W2783180147 cites W2100846474 @default.
• W2783180147 cites W2101363175 @default.
• W2783180147 cites W2101667799 @default.
• W2783180147 cites W2103037576 @default.
• W2783180147 cites W2104227586 @default.
• W2783180147 cites W2104968232 @default.
• W2783180147 cites W2105663540 @default.
• W2783180147 cites W2117844350 @default.
• W2783180147 cites W2122082443 @default.
• W2783180147 cites W2124077349 @default.
• W2783180147 cites W2138465150 @default.
• W2783180147 cites W2143921328 @default.
• W2783180147 cites W2146976930 @default.
• W2783180147 cites W2148945613 @default.
• W2783180147 cites W2150148667 @default.
• W2783180147 cites W2156327548 @default.
• W2783180147 cites W2157317643 @default.
• W2783180147 cites W2159118237 @default.
• W2783180147 cites W2160935383 @default.
• W2783180147 cites W2161031490 @default.
• W2783180147 cites W2162189519 @default.
• W2783180147 cites W2265455913 @default.
• W2783180147 cites W2299896901 @default.
• W2783180147 cites W2335534790 @default.
• W2783180147 cites W2462769577 @default.
• W2783180147 cites W2510727969 @default.
• W2783180147 cites W2511335713 @default.
• W2783180147 cites W2524968585 @default.
• W2783180147 cites W2587079693 @default.
• W2783180147 cites W2746870493 @default.
• W2783180147 cites W4231517048 @default.
• W2783180147 cites W4253284576 @default.
• W2783180147 doi "https://doi.org/10.1016/j.nbd.2018.01.007" @default.
• W2783180147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5851450" @default.
• W2783180147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29331263" @default.
• W2783180147 hasPublicationYear "2018" @default.
• W2783180147 type Work @default.
• W2783180147 sameAs 2783180147 @default.
• W2783180147 citedByCount "74" @default.
• W2783180147 countsByYear W27831801472018 @default.
• W2783180147 countsByYear W27831801472019 @default.
• W2783180147 countsByYear W27831801472020 @default.

• next