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• W2783444787 abstract "Pituitary radiotherapy (RT) has undergone important progress in the last decades due to the development of new stereotactic techniques which provide more precise tumour targeting with less overall radiation received by the adjacent brain structures. Pituitary surgery is usually first-line therapy in most patients with nonfunctioning (NFPA) and functioning adenomas (except for prolactinomas and large growth hormone (GH) secreting adenomas), while RT is used as second or third-line therapy. The benefits of RT (tumour volume control and, in functional tumours, decreased hormonal secretion) are hampered by the long latency of the effect and the potential side effects. This review presents the updates in the efficacy and safety of the new stereotactic radiation techniques in patients with NFPA, GH-, ACTH- or PRL-secreting pituitary adenomas.A systematic review was performed using PubMed and articles/abstracts and reviews detailing RT in pituitary adenomas from 2000 to 2017 were included.Stereotactic radiosurgery (SRS) and fractionated stereotactic RT (FSRT) provide high rates of tumour control i.e. stable or decrease in tumour size, in all types of pituitary adenomas (median 92 - 98%) at 5 years. Endocrinological remission is however significantly lower: 44-52% in acromegaly, 54-64% in Cushing's disease and around 30% in prolactinomas at 5 years. The rate of new hypopituitarism varies from 10% to 50% at 5 years in all tumour types and as expected increases with the duration of follow-up (FU). The risk for other radiation-induced complications is usually low (0-5% for new visual deficits, cranial nerves damage or brain radionecrosis and extremely low for secondary brain tumours), however longer FU is needed to determine rates of secondary tumours. Notably, in acromegaly, there may be a higher risk for stroke with FSRT.Stereotactic radiotherapy can be an effective treatment option for patients with persistent or recurrent pituitary adenomas after unsuccessful surgery (especially if residual tumour is enlarging) and/or resistance or unavailability of medical therapy. Comparison with conventional radiation therapy (CRT) is rather difficult, due to the substantial heterogeneity of the studies. In order to evaluate the potential brain-sparing effect of the new stereotactic techniques, suggested by the current data, long-term studies evaluating secondary morbidity and mortality are needed." @default.
• W2783444787 created "2018-01-26" @default.
• W2783444787 creator A5045002153 @default.
• W2783444787 creator A5065381880 @default.
• W2783444787 date "2017-01-01" @default.
• W2783444787 modified "2023-10-16" @default.
• W2783444787 title "Stereotactic Radiation Therapy in Pituitary Adenomas, is it Better than Conventional Radiation Therapy" @default.
• W2783444787 cites W1479805781 @default.
• W2783444787 cites W1534892562 @default.
• W2783444787 cites W1543944539 @default.
• W2783444787 cites W1582738405 @default.
• W2783444787 cites W1649703361 @default.
• W2783444787 cites W1910274646 @default.
• W2783444787 cites W1946116870 @default.
• W2783444787 cites W1963966171 @default.
• W2783444787 cites W1964671363 @default.
• W2783444787 cites W1966259253 @default.
• W2783444787 cites W1967101960 @default.
• W2783444787 cites W1970049662 @default.
• W2783444787 cites W1970121215 @default.
• W2783444787 cites W1971710427 @default.
• W2783444787 cites W1972338828 @default.
• W2783444787 cites W1973460582 @default.
• W2783444787 cites W1978732716 @default.
• W2783444787 cites W1979232730 @default.
• W2783444787 cites W1979748274 @default.
• W2783444787 cites W1988787595 @default.
• W2783444787 cites W1990927040 @default.
• W2783444787 cites W1992537443 @default.
• W2783444787 cites W1993849492 @default.
• W2783444787 cites W1995656165 @default.
• W2783444787 cites W1996546065 @default.
• W2783444787 cites W2001077013 @default.
• W2783444787 cites W2002070825 @default.
• W2783444787 cites W2003115655 @default.
• W2783444787 cites W2005021430 @default.
• W2783444787 cites W2007956690 @default.
• W2783444787 cites W2009987552 @default.
• W2783444787 cites W2010288774 @default.
• W2783444787 cites W2011162641 @default.
• W2783444787 cites W2012852341 @default.
• W2783444787 cites W2013080895 @default.
• W2783444787 cites W2014450976 @default.
• W2783444787 cites W2015570393 @default.
• W2783444787 cites W2017283375 @default.
• W2783444787 cites W2019055295 @default.
• W2783444787 cites W2019414010 @default.
• W2783444787 cites W2020134167 @default.
• W2783444787 cites W2020703659 @default.
• W2783444787 cites W2024424969 @default.
• W2783444787 cites W2025188641 @default.
• W2783444787 cites W2027794460 @default.
• W2783444787 cites W2027905102 @default.
• W2783444787 cites W2028038613 @default.
• W2783444787 cites W2029253608 @default.
• W2783444787 cites W2029304376 @default.
• W2783444787 cites W2029839755 @default.
• W2783444787 cites W2030838598 @default.
• W2783444787 cites W2032132308 @default.
• W2783444787 cites W2033066182 @default.
• W2783444787 cites W2033750059 @default.
• W2783444787 cites W2034538145 @default.
• W2783444787 cites W2037301907 @default.
• W2783444787 cites W2037972154 @default.
• W2783444787 cites W2040844610 @default.
• W2783444787 cites W2045171408 @default.
• W2783444787 cites W2045311197 @default.
• W2783444787 cites W2046834769 @default.
• W2783444787 cites W2048030025 @default.
• W2783444787 cites W2051483640 @default.
• W2783444787 cites W2052625810 @default.
• W2783444787 cites W2052979680 @default.
• W2783444787 cites W2054713411 @default.
• W2783444787 cites W2058560205 @default.
• W2783444787 cites W2062256560 @default.
• W2783444787 cites W2065177230 @default.
• W2783444787 cites W2066646119 @default.
• W2783444787 cites W2066759952 @default.
• W2783444787 cites W2066862078 @default.
• W2783444787 cites W2068204593 @default.
• W2783444787 cites W2076801920 @default.
• W2783444787 cites W2076994318 @default.
• W2783444787 cites W2079605343 @default.
• W2783444787 cites W2081997942 @default.
• W2783444787 cites W2082107497 @default.
• W2783444787 cites W2087777302 @default.
• W2783444787 cites W2088653136 @default.
• W2783444787 cites W2089506288 @default.
• W2783444787 cites W2091928001 @default.
• W2783444787 cites W2093504923 @default.
• W2783444787 cites W2101108938 @default.
• W2783444787 cites W2104175834 @default.
• W2783444787 cites W2113359125 @default.
• W2783444787 cites W2113564109 @default.
• W2783444787 cites W2115380138 @default.
• W2783444787 cites W2115889772 @default.
• W2783444787 cites W2119847613 @default.
• W2783444787 cites W2126750918 @default.

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