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- W2784103660 startingPage "e1007166" @default.
- W2784103660 abstract "Previous studies have shown that translation elongation is regulated by multiple factors, but the observed heterogeneity remains only partially explained. To dissect quantitatively the different determinants of elongation speed, we use probabilistic modeling to estimate initiation and local elongation rates from ribosome profiling data. This model-based approach allows us to quantify the extent of interference between ribosomes on the same transcript. We show that neither interference nor the distribution of slow codons is sufficient to explain the observed heterogeneity. Instead, we find that electrostatic interactions between the ribosomal exit tunnel and specific parts of the nascent polypeptide govern the elongation rate variation as the polypeptide makes its initial pass through the tunnel. Once the N-terminus has escaped the tunnel, the hydropathy of the nascent polypeptide within the ribosome plays a major role in modulating the speed. We show that our results are consistent with the biophysical properties of the tunnel." @default.
- W2784103660 created "2018-01-26" @default.
- W2784103660 creator A5012430778 @default.
- W2784103660 creator A5050837693 @default.
- W2784103660 date "2018-01-16" @default.
- W2784103660 modified "2023-10-13" @default.
- W2784103660 title "The impact of ribosomal interference, codon usage, and exit tunnel interactions on translation elongation rate variation" @default.
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- W2784103660 doi "https://doi.org/10.1371/journal.pgen.1007166" @default.
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- W2784103660 hasPublicationYear "2018" @default.
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